Strain information  NBRP Rat No: 1058  Strain name: WIET.Cg-Mod/Iet  Commmon Name: MOD Principal Investigator:  Akira Sato  The Institute of Environmental Toxicology           303-0043      Japan Tel: 0297-27-4537    Fax: 0297-27-4519 Email: a.satoh@iet.or.jp Preservation Status:   Embryo        Sperm       Living Animals Coat Color  albino Inbred Generations  F?+25 Usage Restrictions  In publishing, a citation of the following literature designated by the DEPOSITOR is requested.　 Kaneda M et al, Heritable oligodactyly occurring only in male rats. Teratology. 1995;51(2):79-84 Genetic Status   Inbred  Segregating   Congenic   Consomic   Recombinant   Coisogenic   Spont. Mutant  Transgene  Ind. Mutant  Category Other  Comercial Availability Research Category   Diabetes Obesity  Neurobiology  Ophthalmology   Dentistry  Cardio Hypertension  Cancer  Metabolism  Otorhinology  Immunology  Infectious  Osteosis   Internal Organ  Dermatology   Reproduction   Development  Behavior  Hematology  Urology   Pharmacology  Research Area Others   Control Strain  Marker Strain Gene Affected YMale oligodactyly (Mod) Origin In 1980, a male with ectrodactyly emerged from a pair of inbred strains (WIET) derived from Jcl:Wistar rats. At the time, the line was maintained by mating ectrodactyly males with WIET females. All males born to ectrodactyly males developed ectrodactyly, while all females were normal, suggesting the presence of the responsible mutation, Mod, on the Y chromosome. Subsequently, a genetic polymorphism (Ms) that completely suppressed the ectrodactyly phenotype was discovered through mating experiments with outbred rats, and this polymorphism was introduced into the line. Currently, the line has been maintained for at least 20 years by selecting males with a normal phenotype (X/Ymod, +/Ms) from the same litter and mating them with WIET females. Strain characteristics Only males develop ectrodactyly and short tails. They are capable of breeding unless the short tail physically prevents the testicles from descending. Breeding Conditions Maintained by mating Ymod-carrying males with normal phenotypes with female WIET rats. This mating yields three types of rats: males with ectrodactyly (X/Ymod, +/+), normal males (X/Ymod, +/Ms), and normal females (X/X, +/+ or +/Ms). Of these, normal males (X/Ymod, +/Ms) are selected for mating in the next generation. Genotyping None References Kaneda M et al, Heritable oligodactyly occurring only in male rats. Teratology. 1995;51(2):79-84. Additional strain information