Strain information
 NBRP Rat No: 0010  Strain name: NER/Kyo  Commmon Name: NER, Noda epileptic rat, GMS Rat Genome Database
Principal Investigator:  Tadao Serikawa  Graduate School of Medicine, Kyoto University       Yoshidakonoe-cho, Sakyo-ku    606-8501 Kyoto     JAPAN
Tel: 075-753-4360    Fax: 075-753-4409 Email: serikawa@anim.med.kyoto-u.ac.jp
Preservation Status:   Embryo        Sperm       Living Animals ../images/Photos/NER/61a%20(Large).jpg ../images/Photos/NER/61%20(Large).jpg
Coat Color  albino (c)
Inbred Generations  F28+42 (March 2012)
Usage Restrictions  The recipient of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR.
For a commercial use of this resource, a new contract must be concluded between the depositor and the recipient.
Genetic Status
 Inbred  Segregating  Congenic  Consomic  Recombinant
 Coisogenic  Spont. Mutant  Transgene  Ind. Mutant  Category Other 
Comercial Availability Japan SLC,Inc.
Research Category
 Diabetes Obesity  Neurobiology  Ophthalmology  Dentistry  Cardio Hypertension
 Cancer  Metabolism  Otorhinology  Immunology  Infectious
 Osteosis  Internal Organ  Dermatology  Reproduction  Development
 Behavior  Hematology  Urology  Pharmacology  Research Area Others 
 Control Strain  Marker Strain
Gene Affected
Origin Noda Epileptic Rat derived from Crj: Wistar rats. Developed by A. Noda, 1985. 1997 introduced to Kyoto University (F28).
Strain characteristics Animal model of epilepsy that exhibit spontaneous tonic-clonic convulsions, beginning with neck and forelimb clonus, wild jumping/running, opisthotonic posturing, and evolving to tonic, then clonic convulsion, followed by postictal flaccidity. Ictal cortical and hippocampal EEGs are characterized by high-voltage spikes followed by diffuse spike-and-wave or polyspike-and-wave complexes. Seizure susceptibility to pentylenetetrazol, tossing, and transcorneal electroshock, but not to tactile, photic, or acoustic stimuli, or to transauricular electroshock. No pathologic changes were demonstrated in the CNS. Spontaneous convulsions are controlled by a major autosomal recessive gene for epilepsy, that are comparable to generalized tonic-clonic seizures in humans (Noda, 1998).
Breeding Conditions Good breeding performance.
Genotyping
References Kuramoto T, Voigt B, Nakanishi S, Kitada K, Nakamura T, Wakamatsu K, Yoshihara M, Suyama M, Uemura R, Tanaka M, Kuwamura M, Shimizu S, Ohno Y, Sasa M, Serikawa T.
Identification of candidate genes for generalized tonic-clonic seizures in Noda epileptic rat.
Behav Genet. 2017

Serikawa T, Mashimo T, Kuramoto T, Voigt B, Ohno Y, Sasa M.
Advances on Genetic Rat Models of Epilepsy.
Exp Anim. 64(1):1-7, 2015.

Harada Y, Nagao Y, Shimizu S, Serikawa T, Terada R, Fujimoto M, Okuda A, Mukai T, Sasa M, Kurachi Y, Ohno Y.
Expressional analysis of inwardly rectifying Kir4. 1 channels in Noda epileptic rat (NER).
Brain Res. 2013 Jun 23;1517:141-9.

Pandit S, Jeong JA, Jo JY, Cho HS, Kim DW, Kim JM, Ryu PD, Lee SY, Kim HW, Jeon BH, Park JB.
Dual mechanisms diminishing tonic GABAA inhibition of dentate gyrus granule cells in Noda epileptic rats.
J Neurophysiol. 2013 Jul;110(1):95-102.

Ishimaru Y, Chiba S, Serikawa T, Sasa M, Inaba H, Tamura Y, Ishimoto T, Takasaki H, Sakamoto K, Yamaguchi K.
Effects of levetiracetam on hippocampal kindling in Noda epileptic rats.
Brain Res. 2010 Jan 14;1309:104-9.

Maihara, T., Noda, A., Yamazoe, H., Voigt, B., Kitada, K. and Serikawa, T.
Chromosomal mapping of genes for epilepsy in NER: A rat strain with tonic-clonic seizures.
Epilepsia, 41 (8): 941-949, 2000.

Sejima, H., Ito, M., Kishi, K., Noda, A. and Serikawa, T.
Regional excitatory and inhibitory amino acid concentrations in Noda epileptic rat (NER) brain.
Brain Develop, 21: 382-385, 1999.

Jinde, S., Masui, A., Morinobu, S., Takahashi, Y., Tsunashima, K., Noda, A., Yamada, N. and Kato, N.
Elevated neuropeptide Y and corticotropin-releasing factor in the brain of a novel epileptic mutant rat: Noda epileptic rat.
Brain Res., 30 (2): 115-126, 1999.

Iida, K., Sasa, M., Serikawa, T., Noda, A., Ishihara, K., Akimitsu, T., Hanaya, R., Arita, K. and Kurisu, K.
Induction of convulsive seizures by acoustic priming in a new genetically defined model of epilepsy (Noda epileptic rat: NER).
Epilepsy Res, 30 : 115-126, 1998

Noda, A., Hashizume, R., Maihara, T., Tomizawa, Y., Ito, Y., Inoue, M., Kobayashi, K., Asano, Y., Sasa, M., Serikawa, T.
NER rat strain, a new type of genetic model in epilepsy research.
Epilepsia, 39 (1): 99-107, 1998.

Sasa、M.,Hanaya, R., Iida, K., Akimitsu, T., Kurisu, K., Noda, A., Kobayashi, K., Asano, Y., Sasa, M. and Serikawa, T.
A novel epilepsy animal model (NER).
Nihon Shinkei Seishin Yakurigaku Zasshi, 17(1): 35-38, 1997 (in Japanese)
Additional strain information NER