| NBRP Rat No: 0139 |
Strain name: LE/Stm |
Commmon Name: |
Rat Genome Database |
| Principal Investigator: |
Ryoji Hokao Institute for Animal Reproduction 1103, Fukaya, Kasumigaura, 300-0131 Ibaraki Japan |
| Tel: 029-897-0631 Fax: 029-897-0633 |
Email: hokao_ryoji@iar.or.jp |
| Preservation Status: |
Embryo Sperm Living Animals |
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| Coat Color |
tan hooded (a,B,C,h,r) |
| Inbred Generations |
F86+2+23 (April 2012) |
| Usage Restrictions |
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| Genetic Status |
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| Comercial Availability |
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| Research Category |
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| Gene Affected |
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| Origin |
The LE/Stm rats were introduced into Saitama Cancer Center Research Institute in 1969 from a closed colony of Long Evans rats maintained in the Ben May Laboratory for Cancer Research, University of Chicago. A mutant with red-eyed dilution was found in 1970 in the Long-Evans colony, and the mutation was fixed by selective mating. Thereafter, they were maintained by sister-brother mating more than F50. |
| Strain characteristics |
A parental strain of LEXF/FXLE RI strains (NBRP No.0105-0138). |
| Breeding Conditions |
Good breeding performance. Sib mating. |
| Genotyping |
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| References |
Yoshihara M, Sato T, Saito D, Ohara O, Kuramoto T, Suyama M.
Application of target capture sequencing of exons and conserved non-coding sequences to 20 inbred rat strains.
Genomics Data. 2016 Dec; 10: 155-157
Igarashi M, Hippo Y, Ochiai M, Fukuda H, Nakagama H.
AKT is critically involved in cooperation between obesity and the dietary carcinogen amino-1-methyl-6-phenylimidazo [4,5-b] (PhIP) toward colon carcinogenesis in rats.
Biochem Biophys Res Commun. 2013 Dec 13. pii: S0006-291X(13)02128-1.
Taketsuru H, Kaneko T.
Efficient collection and cryopreservation of embryos in F344 strain inbred rats.
Cryobiology. 2013 Oct;67(2):230-4.
Atanur SS, Diaz AG, Maratou K, Sarkis A, Rotival M, Game L, Tschannen MR, Kaisaki PJ, Otto GW, Ma MC, Keane TM, Hummel O, Saar K, Chen W, Guryev V, Gopalakrishnan K, Garrett MR, Joe B, Citterio L, Bianchi G, McBride M, Dominiczak A, Adams DJ, Serikawa T, Flicek P, Cuppen E, Hubner N, Petretto E, Gauguier D, Kwitek A, Jacob H, Aitman TJ.
Genome Sequencing Reveals Loci under Artificial Selection that Underlie Disease Phenotypes in the Laboratory Rat.
Cell. 2013 Aug 1;154(3):691-703.
Amelie Baud, Roel Hermsen, Victor Guryev, Pernilla Stridh, Delyth Graham, Martin W McBride, Tatiana Foroud, Sophie Calderari, Margarita Diez, Johan Ockinger, Amennai D Beyeen. Alan Gillett, Nada Abdelmagid, Andre Ortlieb Guerreiro-Cacais, Maja Jagodic, Jonatan Tuncel, Ulrika Norin, Elisabeth Beattie, Ngan Huynh, William H Miller, Daniel L Koller, Imranul Alam,
Samreen Falak, Mary Osborne-Pellegrin, Esther Martinez-Membrives et al.
Combined sequence-based and genetic mapping analysis of complex traits in outbred rats.
Nat Genet. 2013 Jul;45(7):767-75.
Lu LM, Shisa H, Tanuma J, Hiai H.
Propylnitrosourea-induced T-lymphomas in LEXF RI strains of rats: genetic analysis.
Br J Cancer. 1999 May;80(5-6):855-61.
Shisa H, Lu L, Katoh H, Kawarai A, Tanuma J, Matsushima Y, Hiai H.
The LEXF: a new set of rat recombinant inbred strains between LE/Stm and F344.
Mamm Genome. 1997 May;8(5):324-7. |
| Additional strain information |
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