Strain information
 NBRP Rat No: 0140  Strain name: F344/Stm  Commmon Name: Rat Genome Database
Principal Investigator:  Ryoji Hokao  Institute for Animal Reproduction       1103, Fukaya, Kasumigaura,     300-0131 Ibaraki     Japan
Tel: 029-897-0631    Fax: 029-897-0633 Email:
Preservation Status:   Embryo        Sperm       Living Animals ../images/Photos/F344%20stm/701a%20(Large).jpg ../images/Photos/F344%20stm/701z%20(Large).jpg
Coat Color  albino (a,B,c,h,R)
Inbred Generations  F64+27 (April 2012)
Usage Restrictions  
Genetic Status
 Inbred  Segregating  Congenic  Consomic  Recombinant
 Coisogenic  Spont. Mutant  Transgene  Ind. Mutant  Category Other 
Comercial Availability
Research Category
 Diabetes Obesity  Neurobiology  Ophthalmology  Dentistry  Cardio Hypertension
 Cancer  Metabolism  Otorhinology  Immunology  Infectious
 Osteosis  Internal Organ  Dermatology  Reproduction  Development
 Behavior  Hematology  Urology  Pharmacology  Research Area Others 
 Control Strain  Marker Strain
Gene Affected
Origin F344/Stm rats were derived from a pair of F344/DuCrj rats purchased from Charles River Japan, Inc. and thereafter maintained by brother-sister matings for >23 generations in Saitama Cancer Center Research Institute.
Strain characteristics A parental strain of LEXF/FXLE RI strains (NBRP No.0105-0138).
This strain has a loss-of-function misssense mutation (Gly633Arg) in DIPEPTIDYL PEPTIDASE IV(Dpp4)gene as F344/DuCrlCrlj strain. (July 7, 2016)
Breeding Conditions Good breeding performance. Sib mating.
References Yoshihara M, Sato T, Saito D, Ohara O, Kuramoto T, Suyama M.
Application of target capture sequencing of exons and conserved non-coding sequences to 20 inbred rat strains.
Genomics Data. 2016 Dec; 10: 155-157

Taketsuru H, Kaneko T.
In vitro maturation of immature rat oocytes under simple culture conditions and subsequent developmental ability.
J Reprod Dev. 2016 Jul 2. [Epub ahead of print]

Nakanishi S, Serikawa T, Kuramoto T.
Slc:Wistar Outbred Rats Show Close Genetic Similarity with F344 Inbred Rats.
Exp Anim. 64(1):25-29, 2015.

Kaneko T, Mashimo T.
Creating Knockout and Knockin Rodents Using Engineered Endonucleases via Direct Embryo Injection.

Methods Mol Biol. 1239:307-315, 2015.

Yoshimi K, Kaneko T, Voigt B, Mashimo T.
Allele-specific genome editing and correction of disease-associated phenotypes in rats using the CRISPR-Cas platform.
Nat Commun. 5:4240, 2014.

Taketsuru H, Kaneko T.
Efficient collection and cryopreservation of embryos in F344 strain inbred rats.
Cryobiology. 2013 Oct;67(2):230-4.

Voigt B, Kuramoto T, Mashimo T, Tsurumi T, Sasaki Y, Hokao R, Serikawa T.
Evaluation of LEXF/FXLE rat recombinant inbred strains for genetic dissection of complex traits.
Physiol Genomics. 2008 Feb 19;32(3):335-42.

Hashimoto R, Voigt B, Ishimaru Y, Hokao R, Chiba S, Serikawa T, Sasa M, Kuramoto T.
Identification of QTLs involved in the development of amygdala kindling in the rat.
Exp Anim. 2013;62(3):181-7.

Shisa, H. et al.
The LEXF:a new set of rat recombinant inbred strains between LE/Stm and F344.
Mamm, Genome.8:324-327(1997).

Lu, L-M., Shisa H. et al.
Propynitrosourea-induced T-lymphomas in LEXF RI strains of rats:genetic analysis.
Br. J.Cancer. 80:855-861(1999)
Additional strain information F344