Strain information  NBRP Rat No: 0141  Strain name: DDI/Ddia  Commmon Name: dokkyo diabetes insipidus rat, M520, 尿崩症ラット Rat Genome Database Principal Investigator:  Sadao Yamaoka  Dokkyo University, School of Medicine       880, Kitakobayashi, Mibu, Shimotsuga    321-0293 Tochigi     Japan Tel: 0282-87-2125    Fax: 0282-87-2125 Email: yamaoka@dokkyomed.ac.jp Preservation Status:   Embryo        Sperm       Living Animals Coat Color   Inbred Generations  F35 (Jun 2010) Usage Restrictions   Genetic Status   Inbred  Segregating   Congenic   Consomic   Recombinant   Coisogenic   Spont. Mutant  Transgene  Ind. Mutant  Category Other  Comercial Availability Research Category   Diabetes Obesity  Neurobiology  Ophthalmology   Dentistry  Cardio Hypertension  Cancer  Metabolism  Otorhinology  Immunology  Infectious  Osteosis   Internal Organ  Dermatology   Reproduction   Development  Behavior  Hematology  Urology   Pharmacology  Research Area Others   Control Strain  Marker Strain Gene Affected arginine vasopressin (Avp) Origin Strain characteristics Homozygous 1bp deletion in Arginine vasopression gene. Large amount of urine. Breeding Conditions Because of large amount of urine, frequent change of bedding material is necessary. Genotyping References Mechaly I, Macari F, Lautier C, Serrano JJ, Cros G, Grigorescu F. Identification and sequence analysis of arginine vasopressin mRNA in normal and Brattleboro rat aortic tissue. Eur J Endocrinol. 1998 Jul;139(1):123-6. Schmale H, Richter D. Single base deletion in the vasopressin gene is the cause of diabetes insipidus in Brattleboro rats. Nature. 1984 Apr 19-25;308(5961):705-9. Additional strain information