Gene Affected
Prkg2: protein kinase, cGMP-dependent, type II
Origin
Miniature Rat Ishikawa derived from a breeding colony of Wistar rats at the Ishikawa Animal Laboratory (Saitama). Introduced to Tokyo Medical College.
Strain characteristics
Experimental model for pituitary miniaturism with an autosomal recessive mode of inheritance. Body growth in MRI was retarded in 56% and 71% of normal control rats for males and females, respectively.
Breeding Conditions
Heterozygous female and homozygous male are selected to cross by the phenotype.
References
Chikuda H, Kugimiya F, Hoshi K, Ikeda T, Ogasawara T, Shimoaka T, Kawano H, Kamekura S, Tsuchida A, Yokoi N, Nakamura K, Komeda K, Chung UI, Kawaguchi H
Cyclic GMP-dependent protein kinase II is a molecular switch from proliferation to hypertrophic differentiation of chondrocytes.
Genes Dev 1;18(19):2418-29, 2004.
Serizawa N.
[Initial characterization of a new miniature animal model in the rat: studies on anatomy, pituitary hormones and GH mRNA in miniature rat Ishikawa]
Nippon Naibunpi Gakkai Zasshi 20;69(1):33-45, 1993.
Tsuchida A, Yokoi N, Namae M, Fuse M, Masuyama T, Sasaki M, Kawazu S, Komeda K.
Phenotypic characterization of the Komeda miniature rat Ishikawa, an animal model of dwarfism caused by a mutation in Prkg2.
Comp Med. 58(6):560-7, 2008.