Strain information
 NBRP Rat No: 0006  Strain name: HTX/Kyo  Commmon Name: HTx, H-Tx Rat Genome Database
Principal Investigator:  Tadao Serikawa  Graduate School of Medicine, Kyoto University       Yoshidakonoe-cho, Sakyo-ku    606-8501 Kyoto     JAPAN
Tel: 075-753-4360    Fax: 075-753-4409 Email: serikawa@anim.med.kyoto-u.ac.jp
Preservation Status:   Embryo        Sperm       Living Animals ../images/Photos/HTX%20Kyo/141a%20(Large).jpg ../images/Photos/HTX%20Kyo/141z%20(Large).jpg
Coat Color  albino (c)
Inbred Generations  F?+54 (March 2012)
Usage Restrictions  
Genetic Status
 Inbred  Segregating  Congenic  Consomic  Recombinant
 Coisogenic  Spont. Mutant  Transgene  Ind. Mutant  Category Other 
Comercial Availability
Research Category
 Diabetes Obesity  Neurobiology  Ophthalmology  Dentistry  Cardio Hypertension
 Cancer  Metabolism  Otorhinology  Immunology  Infectious
 Osteosis  Internal Organ  Dermatology  Reproduction  Development
 Behavior  Hematology  Urology  Pharmacology  Research Area Others 
 Control Strain  Marker Strain
Gene Affected
Origin 1981 by Kohn from institutional albino rats of unknown origin at University of Texas. From Juntendo University to Kyoto University in 1992.
Strain characteristics Hydrocephalics can be detected at 1-2 days of age, and survive for 4-5 weeks. Dilatation of the ventricles is restricted to the lateral ventricles (Kohn et al. 1981). Hydrocephalus becomes evident in late gestation and is associated with an abnormality of the cerebral aqueduct (Jones and Bucknall 1988). Overall, penetrance in this strain is 40% but variable between litters, which may indicate the involvement of environmental factors of yet unknown origin, in addition to genetic factors.
Breeding Conditions Animals which don't describe the mutant phenotype are selected for mating.
Genotyping
References Kim H, Yoshihara M, Suyama M.
Comparative genomic analysis of inbred rat strains reveals the existence of ancestral polymorphisms.
Mamm Genome. 2020 Apr;31(3-4):86-94.

Yoshihara M, Sato T, Saito D, Ohara O, Kuramoto T, Suyama M.
Application of target capture sequencing of exons and conserved non-coding sequences to 20 inbred rat strains.
Genomics Data. 2016 Dec; 10: 155-157

Jones HC, Depelteau JS, Carter BJ, Lopman BA, Morel L.
Genome-wide linkage analysis of inherited hydrocephalus in the H-Tx rat.
Mamm Genome 12:22-26, 2001.

Jones HC, Lopman BA, Jones TW, Morel LM.
Breeding characteristics and genetic analysis of the H-Tx rat strain.
European Journal of Pediatric Surgery. 9 Suppl 1: 42-43, 1999.
Additional strain information HTX