Origin
1981 by Kohn from institutional albino rats of unknown origin at University of Texas. From Juntendo University to Kyoto University in 1992.
Strain characteristics
Hydrocephalics can be detected at 1-2 days of age, and survive for 4-5 weeks. Dilatation of the ventricles is restricted to the lateral ventricles (Kohn et al. 1981). Hydrocephalus becomes evident in late gestation and is associated with an abnormality of the cerebral aqueduct (Jones and Bucknall 1988). Overall, penetrance in this strain is 40% but variable between litters, which may indicate the involvement of environmental factors of yet unknown origin, in addition to genetic factors.
Breeding Conditions
Animals which don't describe the mutant phenotype are selected for mating.
References
Kim H, Yoshihara M, Suyama M.
Comparative genomic analysis of inbred rat strains reveals the existence of ancestral polymorphisms.
Mamm Genome. 2020 Apr;31(3-4):86-94.
Yoshihara M, Sato T, Saito D, Ohara O, Kuramoto T, Suyama M.
Application of target capture sequencing of exons and conserved non-coding sequences to 20 inbred rat strains.
Genomics Data. 2016 Dec; 10: 155-157
Jones HC, Depelteau JS, Carter BJ, Lopman BA, Morel L.
Genome-wide linkage analysis of inherited hydrocephalus in the H-Tx rat.
Mamm Genome 12:22-26, 2001.
Jones HC, Lopman BA, Jones TW, Morel LM.
Breeding characteristics and genetic analysis of the H-Tx rat strain.
European Journal of Pediatric Surgery. 9 Suppl 1: 42-43, 1999.