Strain information
NBRP Rat No: 0031
Strain name
: BB.PVG-
RT1
u/a
/Tky
Commmon Name: BB.PVG-
RT1
u/a
Rat Genome Database
Principal Investigator:
Eiichi Kawamoto Tokyo Medical University 6-1-1 Shinjuku, Shinjuku-ku, 160-8402 Tokyo JAPAN
Tel: 03-3351-6141 Fax: 03-3350-8689
Email: kawamoto@tokyo-med.ac.jp
Preservation Status:
Embryo
Sperm
Living Animals
Coat Color
albino (c)
Inbred Generations
N11
Usage Restrictions
Genetic Status
Inbred
Segregating
Congenic
Consomic
Recombinant
Coisogenic
Spont. Mutant
Transgene
Ind. Mutant
Category Other
Comercial Availability
Research Category
Diabetes Obesity
Neurobiology
Ophthalmology
Dentistry
Cardio Hypertension
Cancer
Metabolism
Otorhinology
Immunology
Infectious
Osteosis
Internal Organ
Dermatology
Reproduction
Development
Behavior
Hematology
Urology
Pharmacology
Research Area Others
Control Strain
Marker Strain
Gene Affected
Origin
A congenic strain with the genetic background of the BB/WorTky strain (RT1.B
u
,D
u
) onto which the MHC locus of PVG.R23 strain (RT1.B
a
,D
a
) has been transferred.
Strain characteristics
Animals carrying u/u alleles of the MHC locus show diabetes and animals carrying a/a alleles show thyroiditis.
Breeding Conditions
Maintained by crossing heterozygotes u/a allele of the MHC locus.
Genotyping
PCR-RFLP
References
Awata T, Guberski DL, Like AA.
Genetics of the BB rat: association of autoimmune disorders (diabetes, insulitis, and thyroiditis) with lymphopenia and major histocompatibility complex class II.
Endocrinology. 1995 Dec;136(12):5731-5.
Additional strain information
BB
PVG