NBRP Rat No: 0174 |
Strain name: WKY.SHRSP-(D1Wox29-D1Arb21)/Izm |
Commmon Name: WKYpch1.0 |
Rat Genome Database |
Principal Investigator: |
Tohru Nabika Shimane University, School of Medicine 89-1 Enya-cho, Izumo 693-8901 Shimane Japan |
Tel: 0853-20-2136 Fax: 0853-20-2135 |
Email: nabika@med.shimane-u.ac.jp |
Preservation Status: |
Embryo Sperm Living Animals |
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Coat Color |
albino (c) |
Inbred Generations |
F12 |
Usage Restrictions |
The recipient of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR. Use of the BIOLOGICAL RESOURCE shall be limited to a collaborative research with the DEPOSITOR. |
Genetic Status |
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Comercial Availability |
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Research Category |
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Gene Affected |
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Origin |
To establish this congenic strain, the QTL region was introgressed from SHRSP/Izm to WKY/Izm by repeated backcrossing following sib-mating. This congenic strain was established to cover the QTL region between D1Wox29 and D1Arb21. |
Strain characteristics |
Hypertension |
Breeding Conditions |
Good breeding performance. |
Genotyping |
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References |
Xiao B, Harada Y, Kawakami K, Nabika T.
A 1.8-Mbp fragment on chromosome 1 affects sympathetic response to stress: evaluation in reciprocal congenic strains between stroke-prone spontaneously hypertensive rat and Wistar-Kyoto rat.
J Hypertens. 2011 Feb;29(2):257-65.
Iigaya K, Kumagai H, Nabika T, Harada Y, Onimaru H, Oshima N, Takimoto C, Kamayachi T, Saruta T, Itoh H.
Relation of blood pressure quantitative trait locus on rat chromosome 1 to hyperactivity of rostral ventrolateral medulla.
Hypertension. 53(1):42-8, 2009.
Wang T, Nabika T, Notsu Y, Takabatake T.
Sympathetic regulation of the renal functions in rats reciprocally congenic for chromosome 1 blood pressure quantitative trait locus.
Hypertens Res. 31(3):561-8, 2008.
Cui ZH, Ikeda K, Kawakami K, GondaT, Nabika T, Masuda J. Exaggerated response to restraint stress in rats congenic for the chromosome 1 blood pressure quantitative trait locus.
Clin Exp Pharmacol Physiol 30:464-469, 2003. |
Additional strain information |
SHRSP |
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