Strain information  NBRP Rat No: 0032  Strain name: KZ-Leprfa/Tky  Commmon Name: KZ-Leprfa, KZF Rat Genome Database Principal Investigator:  Eiichi Kawamoto  Tokyo Medical University       6-1-1 Shinjuku, Shinjuku-ku,    160-8402 Tokyo     JAPAN Tel: 03-3351-6141    Fax: 03-3350-8689 Email: kawamoto@tokyo-med.ac.jp Preservation Status:   Embryo        Sperm       Living Animals Coat Color  black hooded (a,B,C,h) or brown hooded ( a,b,C,h) Inbred Generations   Usage Restrictions   Genetic Status   Inbred  Segregating   Congenic   Consomic   Recombinant   Coisogenic   Spont. Mutant  Transgene  Ind. Mutant  Category Other  Comercial Availability Research Category   Diabetes Obesity  Neurobiology  Ophthalmology   Dentistry  Cardio Hypertension  Cancer  Metabolism  Otorhinology  Immunology  Infectious  Osteosis   Internal Organ  Dermatology   Reproduction   Development  Behavior  Hematology  Urology   Pharmacology  Research Area Others   Control Strain  Marker Strain Gene Affected Lepr: leptin receptor Origin A inbred strain from Zucker-fatty rats which were introduced to Takeda Chemical Industries in 1980. Strain characteristics An autosomal recessive mutation fatty (fa) was caused of the missense mutation of the Lepr gene. Breeding Conditions Maintained by crossing heterozygotes of the Lepr locus. Genotyping PCR-RFLP Genotyping protocol for Lepr References Nakanishi S, Kuramoto T, Kashiwazaki N, Yokoi N. Genetic profiling of two phenotypically distinct outbred rats derived from a colony of the Zucker fatty rats maintained at the Tokyo Medical University. Exp Anim. 2016 Oct 31. [Epub ahead of print] Liang-Cai Zhao, Xiao-Dong Zhang, Heyo Wang, and Donghai Lin. 1H NMR-BASED METABONOMIC ANALYSIS OF METABOLIC CHANGES OF SERUM AND LIVER IN ZUCKER OBESE RATS. Taylor & Francis Analytical Letters, 2011, 44, 1579-1590 Zhao LC, Zhang XD, Liao SX, Gao HC, Wang HY, Lin DH. A metabonomic comparison of urinary changes in Zucker and GK rats. J Biomed Biotechnol. 2010;2010:431894. Additional strain information KZ-Leprfa