Strain information  NBRP Rat No: 0148  Strain name: Gunn-Ugt1a1j/Slc  Commmon Name: Gunn/Slc-j/j, Gunn's (Nonhemolytic jaundiced rat) Rat Genome Database Principal Investigator:  Representative Director  Japan SLC, Inc       3371-8, Kotoh-cho, Hamamatsu    431-1103 Shizuoka     Japan Tel: 053-486-3178    Fax: 053-486-3156 Email: slc01@jslc.co.jp Preservation Status:   Embryo        Sperm       Living Animals Coat Color  black hooded Inbred Generations  F32+54 Usage Restrictions   Genetic Status   Inbred  Segregating   Congenic   Consomic   Recombinant   Coisogenic   Spont. Mutant  Transgene  Ind. Mutant  Category Other  Comercial Availability Japan SLC, Inc Research Category   Diabetes Obesity  Neurobiology  Ophthalmology   Dentistry  Cardio Hypertension  Cancer  Metabolism  Otorhinology  Immunology  Infectious  Osteosis   Internal Organ  Dermatology   Reproduction   Development  Behavior  Hematology  Urology   Pharmacology  Research Area Others   Control Strain  Marker Strain Gene Affected Ugt1a1: UDP glycosyltransferase 1 family, polypeptide A1 Origin Originated from mutant rat found in Wistar rat. Strain characteristics The Gunn rat is a mutant strain of Wistar rat which has unconjugated hyperbilirubinemia as a result of the absence of hepatic UDP-glucuronosyltransferase (UDPGT) activity toward bilirubin. Caused by a single guanosine (G) base deletion within the UGT1A1 gene. Animal model of Crigler–Najjar syndrome type I. (Mar 2008) Breeding Conditions Sib mating. Heterozygous female and homozygous male are mated. Poor breeding performance. Genotyping References Iyanagi T, Watanabe T, Uchiyama Y. The 3-methylcholanthrene-inducible UDP-glucuronosyltransferase deficiency in the hyperbilirubinemic rat (Gunn rat) is caused by a -1 frameshift mutation. J Biol Chem. 1989 Dec 15;264(35):21302-7. Additional strain information Gunn