Strain information
NBRP Rat No: 0153
Strain name
: NAR/Slc
Commmon Name: Nagase analbuminemic rat
Rat Genome Database
Principal Investigator:
Representative Director Japan SLC, Inc 3371-8, Kotoh-cho, Hamamatsu 431-1103 Shizuoka Japan
Tel: 053-486-3178 Fax: 053-486-3156
Email: slc01@jslc.co.jp
Preservation Status:
Embryo
Sperm
Living Animals
Coat Color
albino (c)
Inbred Generations
F44+15
Usage Restrictions
Genetic Status
Inbred
Segregating
Congenic
Consomic
Recombinant
Coisogenic
Spont. Mutant
Transgene
Ind. Mutant
Category Other
Comercial Availability
Research Category
Diabetes Obesity
Neurobiology
Ophthalmology
Dentistry
Cardio Hypertension
Cancer
Metabolism
Otorhinology
Immunology
Infectious
Osteosis
Internal Organ
Dermatology
Reproduction
Development
Behavior
Hematology
Urology
Pharmacology
Research Area Others
Control Strain
Marker Strain
Gene Affected
Origin
Originated from analbuminemic rats found in the closed colony of SD (Jcl:SD).
Strain characteristics
Analbuminemia. Inherited as an autosomal recessive trait. Total serum protein in the mutant rat was similar to that of control Sprague-Dawley rats, with increased globulin. No expression of serum albumin is due to skipping of the exon H caused by a mutation in the intron HI.
Breeding Conditions
Sib mating.
Genotyping
References
Nagase S, Shimamune K, Shumiya S.
Science. 1979 Aug 10;205(4406):590-1.
Albumin-deficient rat mutant.
Hitomi Y, Sugiyama K, Esumi H.
Suppression of the 5' splice site mutation in the Nagase analbuminemic rat with mutated U1snRNA.
Biochem Biophys Res Commun. 1998 Oct 9;251(1):11-6.
Additional strain information
NAR