Strain information
 NBRP Rat No: 0153  Strain name: NAR/Slc  Commmon Name: Nagase analbuminemic rat Rat Genome Database
Principal Investigator:  Representative Director  Japan SLC, Inc       3371-8, Kotoh-cho, Hamamatsu    431-1103 Shizuoka     Japan
Tel: 053-486-3178    Fax: 053-486-3156 Email: slc01@jslc.co.jp
Preservation Status:   Embryo        Sperm       Living Animals ../images/Photos/NAR_Slc/391a%20(Large).jpg ../images/Photos/NAR_Slc/391z%20(Large).jpg
Coat Color  albino (c)
Inbred Generations  F44+15
Usage Restrictions  
Genetic Status
 Inbred  Segregating  Congenic  Consomic  Recombinant
 Coisogenic  Spont. Mutant  Transgene  Ind. Mutant  Category Other 
Comercial Availability
Research Category
 Diabetes Obesity  Neurobiology  Ophthalmology  Dentistry  Cardio Hypertension
 Cancer  Metabolism  Otorhinology  Immunology  Infectious
 Osteosis  Internal Organ  Dermatology  Reproduction  Development
 Behavior  Hematology  Urology  Pharmacology  Research Area Others 
 Control Strain  Marker Strain
Gene Affected
Origin Originated from analbuminemic rats found in the closed colony of SD (Jcl:SD).
Strain characteristics Analbuminemia. Inherited as an autosomal recessive trait. Total serum protein in the mutant rat was similar to that of control Sprague-Dawley rats, with increased globulin. No expression of serum albumin is due to skipping of the exon H caused by a mutation in the intron HI.
Breeding Conditions Sib mating.
Genotyping
References Masayuki Fukumoto, Akihiko Soyama, Daisuke Miyamoto, Takanobu Hara, Hajime Matsushima, Hajime Imamura, Mampei Yamashita, Tomohiko Adachi, Kengo Kanetaka, Susumu Eguchi
Transplantation of chemically induced liver progenitors in Nagase analbuminemic rats under liver regenerative stimulus
Regenerative Therapy. Dec 2025, P1-8. doi: 10.1016/j.reth.2025.04.015

Nagase S, Shimamune K, Shumiya S.
Science. 1979 Aug 10;205(4406):590-1.
Albumin-deficient rat mutant.

Hitomi Y, Sugiyama K, Esumi H.
Suppression of the 5' splice site mutation in the Nagase analbuminemic rat with mutated U1snRNA.
Biochem Biophys Res Commun. 1998 Oct 9;251(1):11-6.
Additional strain information NAR