Strain information
 NBRP Rat No: 0166  Strain name: SD-Tg(CAG-Rgn)Slc  Commmon Name: RC-Tg, SD-Tg(CAG-RGN) Rat Genome Database
Principal Investigator:  Sadaaki Takagi  Japan SLC, Inc       3371-8, Kotoh-cho, Hamamatsu    431-1103 Shizuoka     Japan
Tel: 053-486-3178    Fax: 053-486-3156 Email: slc01@jslc.co.jp
Preservation Status:   Embryo        Sperm       Living Animals ../images/Photos/RC-Tg/651a%20(Large).jpg ../images/Photos/RC-Tg/651z%20(Large).jpg
Coat Color  albino (c)
Inbred Generations  F?+2
Usage Restrictions  The user shall comply with the agreement written by Japan SLC, Inc.
Genetic Status
 Inbred  Segregating  Congenic  Consomic  Recombinant
 Coisogenic  Spont. Mutant  Transgene  Ind. Mutant  Category Other 
Comercial Availability Japan SLC, Inc
Research Category
 Diabetes Obesity  Neurobiology  Ophthalmology  Dentistry  Cardio Hypertension
 Cancer  Metabolism  Otorhinology  Immunology  Infectious
 Osteosis  Internal Organ  Dermatology  Reproduction  Development
 Behavior  Hematology  Urology  Pharmacology  Research Area Others 
 Control Strain  Marker Strain
Gene Affected Rgn: regucalcin
Origin Rats were generated by pronuclear injection of the transgene with a cDNA construct encoding rat regucalcin, a regulatory protein of Ca2+ signaling (Yamaguchi, 2002). (Nov 2009)
Strain characteristics This transgenic strain shows overexpression of regucalcin. Animal model for bone disease as represented by bone loss. The body weight of tg rats is significantly lowered. (Yamaguchi, 2002) (Nov 2009)
Breeding Conditions Sib mating.
Genotyping
References Yamaguchi M, Morooka Y, Misawa H, Tsurusaki Y, Nakajima R.
Role of endogenous regucalcin in transgenic rats: suppression of kidney cortex cytosolic protein phosphatase activity and enhancement of heart muscle microsomal Ca2+-ATPase activity.
J Cell Biochem. 2002;86(3):520-9.
Additional strain information