Strain information  NBRP Rat No: 0166  Strain name: SD-Tg(CAG-Rgn)Slc  Commmon Name: RC-Tg, SD-Tg(CAG-RGN) Rat Genome Database Principal Investigator:  Representative Director  Japan SLC, Inc       3371-8, Kotoh-cho, Hamamatsu    431-1103 Shizuoka     Japan Tel: 053-486-3178    Fax: 053-486-3156 Email: slc01@jslc.co.jp Preservation Status:   Embryo        Sperm       Living Animals Coat Color  albino (c) Inbred Generations  F?+2 Usage Restrictions   Genetic Status   Inbred  Segregating   Congenic   Consomic   Recombinant   Coisogenic   Spont. Mutant  Transgene  Ind. Mutant  Category Other  Comercial Availability Research Category   Diabetes Obesity  Neurobiology  Ophthalmology   Dentistry  Cardio Hypertension  Cancer  Metabolism  Otorhinology  Immunology  Infectious  Osteosis   Internal Organ  Dermatology   Reproduction   Development  Behavior  Hematology  Urology   Pharmacology  Research Area Others   Control Strain  Marker Strain Gene Affected Rgn: regucalcin Origin Rats were generated by pronuclear injection of the transgene with a cDNA construct encoding rat regucalcin, a regulatory protein of Ca2+ signaling (Yamaguchi, 2002). (Nov 2009) Strain characteristics This transgenic strain shows overexpression of regucalcin. Animal model for bone disease as represented by bone loss. The body weight of tg rats is significantly lowered. (Yamaguchi, 2002) (Nov 2009) Breeding Conditions Sib mating. Genotyping References Yamaguchi M, Morooka Y, Misawa H, Tsurusaki Y, Nakajima R. Role of endogenous regucalcin in transgenic rats: suppression of kidney cortex cytosolic protein phosphatase activity and enhancement of heart muscle microsomal Ca2+-ATPase activity. J Cell Biochem. 2002;86(3):520-9. Additional strain information