Strain information
 NBRP Rat No: 0178  Strain name: F344.Z-Leprfa/Tj  Commmon Name: F.ZF-lepr Rat Genome Database
Principal Investigator:  Kozo Matsumoto  The University of Tokushima Graduate School of Medicine       3-18-15 Kuramoto-cho    770-8503 Tokushima     JAPAN
Tel: 088-633-9278    Fax: 088-600-9429 Email:
Preservation Status:   Embryo        Sperm       Living Animals ../images/Photos/ ../images/Photos/
Coat Color  
Inbred Generations  N(6)F4
Usage Restrictions  
Genetic Status
 Inbred  Segregating  Congenic  Consomic  Recombinant
 Coisogenic  Spont. Mutant  Transgene  Ind. Mutant  Category Other 
Comercial Availability
Research Category
 Diabetes Obesity  Neurobiology  Ophthalmology  Dentistry  Cardio Hypertension
 Cancer  Metabolism  Otorhinology  Immunology  Infectious
 Osteosis  Internal Organ  Dermatology  Reproduction  Development
 Behavior  Hematology  Urology  Pharmacology  Research Area Others 
 Control Strain  Marker Strain
Gene Affected Lepr: leptin receptor
Origin Established as speed congenics (5 generations, microsatellite marker) at the University of Tokushima School of Medicine, Institute for Animal Experimentation in 2001. Afterwards, maintained by sib mating.
Strain characteristics Obesity. Show mild hyperglycemia in the OGTT assay.
Breeding Conditions Good breeding performance.
Genotyping Genotyping protocol for Lepr
References Kose H, Yamada T, Matsumoto K.
Single Diabetic QTL Derived from OLETF Rat Is a Sufficient Agent for Severe Diabetic Phenotype in Combination with Leptin-Signaling Deficiency.
Exp Diabetes Res. 2012;2012:858121.Epub 2012 Dec 5.
Additional strain information