Strain information

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NBRP Rat No: 0179

Strain name: F344.Cg-Lepr^fa(D7Rat16-D7Mgh20)/Tj

Commmon Name: F.ZF/O-lepr,Nidd1/of

Rat Genome Database

Principal Investigator:

Kozo MatsumotoThe University of Tokushima Graduate School of Medicine

Preservation Status:

Embryo Sperm Living Animals

Coat Color

Inbred Generations

N(5)F4

Usage Restrictions

Genetic Status

Inbred Segregating Congenic Consomic Recombinant Coisogenic Spont. Mutant Transgene Ind. Mutant Category Other

Comercial Availability

Research Category

Diabetes Obesity Neurobiology Ophthalmology Dentistry Cardio Hypertension Cancer Metabolism Otorhinology Immunology Infectious Osteosis Internal Organ Dermatology Reproduction Development Behavior Hematology Urology Pharmacology Research Area Others

Control Strain Marker Strain

Gene Affected

Origin

Established as speed congenics (5 generations, microsatellite marker) at the University of Tokushima School of Medicine, Institute for Animal Experimentation in 2002. Afterwards, maintained by sib mating.

Strain characteristics

Obesity. Show hyperglycemia in the OGTT assay.

Breeding Conditions

Good breeding performance.

Genotyping

References

Kose H, Yamada T, Matsumoto K.
Single Diabetic QTL Derived from OLETF Rat Is a Sufficient Agent for Severe Diabetic Phenotype in Combination with Leptin-Signaling Deficiency.
Exp Diabetes Res. 2012;2012:858121.Epub 2012 Dec 5.

Additional strain information (Japanese only)