Strain information  NBRP Rat No: 0007  Strain name: KHR/Kyo  Commmon Name: KHR, kaken hairless rat Rat Genome Database Principal Investigator:  Tadao Serikawa  Graduate School of Medicine, Kyoto University       Yoshidakonoe-cho, Sakyo-ku    606-8501 Kyoto     JAPAN Tel: 075-753-4360    Fax: 075-753-4409 Email: serikawa@anim.med.kyoto-u.ac.jp Preservation Status:   Embryo        Sperm       Living Animals Coat Color  albino (c,p) Inbred Generations  F36+31 (March 2012) Usage Restrictions   Genetic Status   Inbred  Segregating   Congenic   Consomic   Recombinant   Coisogenic   Spont. Mutant  Transgene  Ind. Mutant  Category Other  Comercial Availability Research Category   Diabetes Obesity  Neurobiology  Ophthalmology   Dentistry  Cardio Hypertension  Cancer  Metabolism  Otorhinology  Immunology  Infectious  Osteosis   Internal Organ  Dermatology   Reproduction   Development  Behavior  Hematology  Urology   Pharmacology  Research Area Others   Control Strain  Marker Strain Gene Affected Origin Kaken hairless rat were detected by Kimura from Gunn's rat at Kaken Pharmaceuticals in 1987. 2002 introduced to Kyoto University (F36). Strain characteristics Hairless. This strain has deletion mutation in Oca2, pink-eyed dilution (Kuramoto, 2005). A 80-kb deletion was identified in the region containing five basic keratin (krt) genes (Kuramoto, 2010). (Jul 4, 2011) Breeding Conditions Heterozygous female and homozygous male are mated. Genotyping References Kuramoto T, Gohma H, Kimura K, Wedekind D, Hedrich HJ, Serikawa T. The rat pink-eyed dilution (p) mutation: an identical intragenic deletion in pink-eye dilute-coat strains and several Wistar-derived albino strains. Mamm Genome. 2005 Sep;16(9):712-9. Takashi Kuramoto, Satoshi Nakanishi, Ken-ichi Yamasaki, Kenta Kumafuji, Yuichi Sakakibara, Yuki Neoda, Akiko Takizawa, Takehito Kaneko, Mito Otsuki, Ryoko Hashimoto, Birger Voigt, Tomoji Mashimo and Tadao Serikawa Genetic Quality Control of the Rat Strains at the National Bio Resource Project-Rat ibc.2010 Volume 2 Article no. 0012 Additional strain information KHR