Strain information  NBRP Rat No: 0194  Strain name: SHRSP/Izm  Commmon Name: Rat Genome Database Principal Investigator:  Yukio Yamori   Disease Model Cooperative Research Association       Seisan Kaihatsukagakukenkyujyo 3F-Simogamo Morimotocho15-Sakyoku    606-0805 Kyoto     Japan Tel: 075-744-0071    Fax: 075-744-0071 Email: dmcra@j.email.ne.jp Preservation Status:   Embryo        Sperm       Living Animals Coat Color  albino (c) Inbred Generations  F110 Usage Restrictions  The recipient of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR. The users must join a disease model cooperative research association, and obey various regulations stipulated in the rules of the association. They must also comply with the decisions made by the board of directors. Genetic Status   Inbred  Segregating   Congenic   Consomic   Recombinant   Coisogenic   Spont. Mutant  Transgene  Ind. Mutant  Category Other  Comercial Availability Research Category   Diabetes Obesity  Neurobiology  Ophthalmology   Dentistry  Cardio Hypertension  Cancer  Metabolism  Otorhinology  Immunology  Infectious  Osteosis   Internal Organ  Dermatology   Reproduction   Development  Behavior  Hematology  Urology   Pharmacology  Research Area Others   Control Strain  Marker Strain Gene Affected Origin The stroke-prone spontaneously hypertensive rat (SHRSP) was established by selective breeding of SHR at the Department of Pathology, Kyoto University School of Medicine in 1973. To Shimane Institute of Health Science, Shimane University Faculty of Medicine, Graduate School of Human and Environmental Studies, Kyoto University and to DMCRA in 1994. Strain characteristics Stroke, hypertension, cardiac hypertrophy and nephrosclerosis. Breeding Conditions Good breeding performance. Genotyping References Yamagata K, Yamamoto M, Kawakami K, Ohara H, Nabika T. Arginine vasopressin regulated ASCT1 expression in astrocytes from stroke-prone spontaneously hypertensive rats and congenic SHRpch1_18 rats. Neuroscience. 267:277-285, 2014. Yao H, Nabika T. Standards and pitfalls of focal ischemia models in spontaneously hypertensive rats: With a systematic review of recent articles. J Transl Med. 2012 Jul 6;10(1):139. Sakurai-Yamashita Y, Nabika T, Niwa M. Blood pressure-independent factors determine the susceptibility to delayed neuronal death in the stroke-prone spontaneously hypertensive rats. Cell Mol Neurobiol. 2010 Mar;30(2):283-7. Yamori,Y et.al. : The Spontaneously Hypertensive Rat. In: Textbook of hypertension, ed. By Swales,J.D.,Blackwell Scientific Publication, Oxford, 1994,pp447-455 Additional strain information SHR