Usage Restrictions
The recipient of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR.
The users must join a disease model cooperative research association, and obey various regulations stipulated in the rules of the association.
They must also comply with the decisions made by the board of directors.
Origin
The stroke-prone spontaneously hypertensive rat (SHRSP) was established by selective breeding of SHR at the Department of Pathology, Kyoto University School of Medicine in 1973. To Shimane Institute of Health Science, Shimane University Faculty of Medicine, Graduate School of Human and Environmental Studies, Kyoto University and to DMCRA in 1994.
Strain characteristics
Stroke, hypertension, cardiac hypertrophy and nephrosclerosis.
Breeding Conditions
Good breeding performance.
References
Yamagata K, Yamamoto M, Kawakami K, Ohara H, Nabika T.
Arginine vasopressin regulated ASCT1 expression in astrocytes from stroke-prone spontaneously hypertensive rats and congenic SHRpch1_18 rats.
Neuroscience. 267:277-285, 2014.
Yao H, Nabika T.
Standards and pitfalls of focal ischemia models in spontaneously hypertensive rats: With a systematic review of recent articles.
J Transl Med. 2012 Jul 6;10(1):139.
Sakurai-Yamashita Y, Nabika T, Niwa M.
Blood pressure-independent factors determine the susceptibility to delayed neuronal death in the stroke-prone spontaneously hypertensive rats.
Cell Mol Neurobiol. 2010 Mar;30(2):283-7.
Yamori,Y et.al. : The Spontaneously Hypertensive Rat. In: Textbook of hypertension,
ed. By Swales,J.D.,Blackwell Scientific Publication, Oxford, 1994,pp447-455