Strain information  NBRP Rat No: 0216  Strain name: LEC(LECSDF1)-Tg(CAG-ATP7B)Tohm  Commmon Name: LEC(LECSDF1)-Tg(hATP7B)Tohm, L2-3 Rat Genome Database Principal Investigator:  Noriyuki Kasai  Tohoku University Graduate School of Medicine       2-1, Seiryo-machi, Aoba-ku, Sendai    980-8575 Miyagi     Japan Tel: 022-717-8178    Fax: 022-717-8180 Email: nkasai@mail.tains.tohoku.ac.jp Preservation Status:   Embryo        Sperm       Living Animals Coat Color  cinnamon Inbred Generations  F5 Usage Restrictions  In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the literature(s) designated by the DEPOSITOR is requested. Genetic Status   Inbred  Segregating   Congenic   Consomic   Recombinant   Coisogenic   Spont. Mutant  Transgene  Ind. Mutant  Category Other  Comercial Availability Research Category   Diabetes Obesity  Neurobiology  Ophthalmology   Dentistry  Cardio Hypertension  Cancer  Metabolism  Otorhinology  Immunology  Infectious  Osteosis   Internal Organ  Dermatology   Reproduction   Development  Behavior  Hematology  Urology   Pharmacology  Research Area Others   Control Strain  Marker Strain Gene Affected ATP7B: ATPase, Cu++ transporting, beta polypeptide Origin Strain characteristics Breeding Conditions Good breeding performance. Genotyping References Meng Y, Miyoshi I, Hirabayashi M, Su M, Mototani Y, Okamura T, Terada K, Ueda M, Enomoto K, Sugiyama T, Kasai N. Restoration of copper metabolism and rescue of hepatic abnormalities in LEC rats, an animal model of Wilson disease, by expression of human ATP7B gene. Biochim Biophys Acta. 5;1690(3):208-19, 2004. Additional strain information LEC