| NBRP Rat No: 0219 |
Strain name: WT/Jtt |
Commmon Name: WT, 切歯白墨化ラット（whitish teeth rat） |
Rat Genome Database |
| Principal Investigator: |
Kazuyuki Taniguchi Iwate University, Faculty of Agriculture 3-18-8 Ueda, Morioka 020-8550 Iwate Japan |
| Tel: 019-621-6207 Fax: 019-621-6209 |
Email: anatomia@iwate-u.ac.jp |
| Preservation Status: |
Embryo Sperm Living Animals |
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| Coat Color |
albino (c) |
| Inbred Generations |
F22 (May 2009) |
| Usage Restrictions |
Use of the BIOLOGICAL RESOURCE shall be limited to a collaborative research with the DEPOSITEOR. |
| Genetic Status |
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| Comercial Availability |
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| Research Category |
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| Gene Affected |
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| Origin |
In 2001, abnormal incisors that had deteriorated and had a whitish chalk-like appearance were unexpectedly discovered in one male rat among Sprague-Dawley [Crj:CD(SD)IGS] rats (Masuyama, 2005). After that, this mutant phenotype was maintained by sib-mating. (Nov 4, 2009) |
| Strain characteristics |
White, chalk-like abnormal incisors. The whitich chalk-like teeth (wct) mutation maps to rat chromosome 14 between D14Got13 and D14Wox2 (Masuyama, 2005). |
| Breeding Conditions |
normal (+/-) × mutant (-/-). Sib mating. |
| Genotyping |
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| References |
Masuyama T, Miyajima K, Ohshima H, Osawa M, Yokoi N, Oikawa T, Taniguchi K.
A novel autosomal-recessive mutation, whitish chalk-like teeth, resembling amelogenesis imperfecta, maps to rat chromosome 14 corresponding to human 4q21.
Eur J Oral Sci. 2005 Dec;113(6):451-6.
Osawa M, Kenmotsu S, Masuyama T, Taniguchi K, Uchida T, Saito C, Ohshima H.
Rat wct mutation prevents differentiation of maturation-stage ameloblasts resulting in hypo-mineralization in incisor teeth.
Histochem Cell Biol. 2007 Sep;128(3):183-93.
Osawa M, Kenmotsu S, Masuyama T, Taniguchi K, Uchida T, Saito C, Ohshima H.
Rat wct mutation induces a hypo-mineralization form of amelogenesis imperfecta and cyst formation in molar teeth.
Cell Tissue Res. 2007 Oct;330(1):97-109. |
| Additional strain information |
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