Strain information
 NBRP Rat No: 0220  Strain name: RICO/Ngs  Commmon Name: rat with increased cholesterol Rat Genome Database
Principal Investigator:  Kazutaka Ohsawa  Center for Frontier Life Sciences, Nagasaki University       1-12-4, Sakamoto, Nagasaki    852-8523 Nagasaki     Japan
Tel: 095-819-7132    Fax: 095-819-7148 Email:
Preservation Status:   Embryo        Sperm       Living Animals ../images/Photos/RICO_Ngs/1271a1024.jpg ../images/Photos/RICO_Ngs/1271z1024.jpg
Coat Color  albino (c)
Inbred Generations  F?+32 (May 2008)
Usage Restrictions  
Genetic Status
 Inbred  Segregating  Congenic  Consomic  Recombinant
 Coisogenic  Spont. Mutant  Transgene  Ind. Mutant  Category Other 
Comercial Availability
Research Category
 Diabetes Obesity  Neurobiology  Ophthalmology  Dentistry  Cardio Hypertension
 Cancer  Metabolism  Otorhinology  Immunology  Infectious
 Osteosis  Internal Organ  Dermatology  Reproduction  Development
 Behavior  Hematology  Urology  Pharmacology  Research Area Others 
 Control Strain  Marker Strain
Gene Affected
Origin In 1969, 2 males and 4 females with spontaneous hypercholesterolemia were selected from different colonies of albino rats. By sib-mating and selective breeding, Muller et al. established this hypercholesterolemic strain and named RICO (rats with increased cholesterol) (Muller, 1979). 1997, from Australia ARC (animal resource centre) to Nagasaki University. (Nov 6, 2009)
Strain characteristics hypercholesterolemia
Breeding Conditions Sib mating. No selective breeding.
References Production hepatique et intestinale de cholesterol augmentee, et quantite augmentee de cholesterol circulant. MULLER et ai., 1979

Müller KR, Li JR, Dinh DM, Subbiah MT.
The characteristics and metabolism of a genetically hypercholesterolemic strain of rats (RICO).
Biochim Biophys Acta. 1979 Aug 30;574(2):334-43.
Additional strain information