| NBRP Rat No: 0241 |
Strain name: DRH.F344-Drh1/Shigm |
Commmon Name: DRH.F344-Drh1 |
Rat Genome Database |
| Principal Investigator: |
Hiroshi Hiai Graduate School of Medicine, Kyoto University Yoshidakonoe-cho, Sakyo-ku 606-8501 Kyoto Japan |
| Tel: 075-753-4421 Fax: 075-753-4432 |
Email: hiai@shigamed.jp |
| Preservation Status: |
Embryo Sperm Living Animals |
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| Coat Color |
albino (c) |
| Inbred Generations |
N16F30 (May 2009) |
| Usage Restrictions |
In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the literature(s) designated by the DEPOSITOR is requested.(see References) |
| Genetic Status |
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| Comercial Availability |
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| Research Category |
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| Gene Affected |
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| Origin |
The DRH is an inbred rat strain established by selective breeding of the 3'-Me-DAB resistant progeny of closed colony Donryu rats over 20 generations. Genetic analysis shows that two semidominant QTLs, Drh1 and Drh2, are responsible for strong resistance to chemical-induced hepatocarcinogenesis in DRH rats. Inbred DRH and F344 rats were purchased from SEAC Yoshitomi Co. DRH. |
| Strain characteristics |
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| Breeding Conditions |
Sib mating. |
| Genotyping |
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| References |
Zeng ZZ, Higashi S, Kitayama W, Denda A, Yan Y, Matsuo K, Konishi Y, Hiai H, Higashi K.
Genetic resistance to chemical carcinogen-induced preneoplastic hepatic lesions in DRH strain rats.
Cancer Res. 2000 Jun 1;60(11):2876-81.
Yan Y, Zeng ZZ, Higashi S, Denda A, Konishi Y, Onishi S, Ueno H, Higashi K, Hiai H.
Resistance of DRH strain rats to chemical carcinogenesis of liver: genetic analysis of later progression stage.
Carcinogenesis. 2002 Jan;23(1):189-96.
Liu H, Nobumoto K, Yamada Y, Higashi K, Hiai H.
Modulation of genetic resistance to hepatocarcinogenesis in DRH rats by partial hepatectomy.
Cancer Lett. 2003 Jun 30;196(1):13-6.
Higashi K, Hiai H, Higashi T, Muramatsu M.
Regulatory mechanism of glutathione S-transferase P-form during chemical hepatocarcinogenesis: old wine in a new bottle.
Cancer Lett. 2004 Jun 25;209(2):155-63.
Liu H, Higashi K, Hiai H.
Role of resistant Drh1 locus in chemical carcinogen-induced hepatocarcinogenesis in rats: analysis with a speed congenic strain.
Cancer Sci. 2005 Mar;96(3):164-9. |
| Additional strain information |
DRH F344 |
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