Strain information
 NBRP Rat No: 0008  Strain name: IS/Kyo  Commmon Name: Ishibashi rat, ISR Rat Genome Database
Principal Investigator:  Tadao Serikawa  Graduate School of Medicine, Kyoto University       Yoshidakonoe-cho, Sakyo-ku    606-8501 Kyoto     JAPAN
Tel: 075-753-4360    Fax: 075-753-4409 Email:
Preservation Status:   Embryo        Sperm       Living Animals ../images/Photos/IS%20Kyo/51a%20(Large).jpg ../images/Photos/IS%20Kyo/51%20(Large).jpg
Coat Color  agouti (A,B,C)
Inbred Generations  F20+68 (March 2012)
Usage Restrictions  The recipient of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR.
For a commercial use of this resource, a new contract must be concluded between the depositor and the recipient.
Genetic Status
 Inbred  Segregating  Congenic  Consomic  Recombinant
 Coisogenic  Spont. Mutant  Transgene  Ind. Mutant  Category Other 
Comercial Availability
Research Category
 Diabetes Obesity  Neurobiology  Ophthalmology  Dentistry  Cardio Hypertension
 Cancer  Metabolism  Otorhinology  Immunology  Infectious
 Osteosis  Internal Organ  Dermatology  Reproduction  Development
 Behavior  Hematology  Urology  Pharmacology  Research Area Others 
 Control Strain  Marker Strain
Gene Affected
Origin Ishibashi rat derived from a cross between a wild male and a Wistar female, with sib mating since 1975 at Azabu University, transferred to Kyoto University in 1978 (IS/Kyo).
Strain characteristics Malformations of the thoracicolumbar vertebrae leading to kyphoscoliosis with restricted spinal canals and compressed spinal cords. The malformations occur from the 12th. thoracic to the 6th. lumbar vertebrae. Up to 7 vertebrae are affected, and some degree of abnormality occurs in 90% of individuals. The expression levels of Hox10 and Hox11 paralogs, which regulate the formation of lumbar and sacral vertebrae, is extremely low in lumbo-sacral transitional areas of ISR compared with those of normal rats (Seki, 2008). The IS rat shows the low plasma alkaline phosphatase (ALP) activity but there is no relations between the ALP activity and the vertebral anomalies (Maekawa, 1982). (Jun 4, 2009)
Breeding Conditions Good breeding performance. Sib mating.
References Yoshihara M, Sato T, Saito D, Ohara O, Kuramoto T, Suyama M.
Application of target capture sequencing of exons and conserved non-coding sequences to 20 inbred rat strains.
Genomics Data. 2016 Dec; 10: 155-157

Tsunoda D, Iizuka H, Ichinose T, Iizuka Y, Mieda T, Shimokawa N, Takagishi K, Koibuchi N.
The Trk family of neurotrophin receptors is downregulated in the lumbar spines of rats with congenital kyphoscoliosis.
Mol Cell Biochem. 2015 Nov 7. [Epub ahead of print]

Takano M, Ogawa E, Saitou T, Yamaguchi Y, Asano Y, Serikawa T, Kuramoto T.
Morphological features of adult rats of IS/Kyo and IS-Tlk/Kyo strains with lumbar and caudal vertebral anomalies.
Exp Anim. 2014;63(3):269-75.

Kuramoto T, Nakanishi S, Ochiai M, Nakagama H, Voigt B, Serikawa T.
Origins of Albino and Hooded Rats: Implications from Molecular Genetic Analysis across Modern Laboratory Rat Strains.
PLoS One. 2012;7(8):e43059.

Torigoe D, Ichii O, Dang R, Ohnaka T, Okano S, Sasaki N, Kon Y, Agui T.
High-resolution linkage mapping of the rat hooded locus.
J Vet Med Sci. 2011 May;73(5):707-10.

Seki T, Shimokawa N, Iizuka H, Takagishi K, Koibuchi N.
Abnormalities of vertebral formation and Hox expression in congenital kyphoscoliotic rats.
Mol Cell Biochem. 312(1-2):193-9, 2008.

Ishibashi M.
Congenital vertebral malformation (Ishibashi rats).
In Handbook on Animal Models of Human Diseases, pp. 430-434, Kawamata J. and Matushita H. (edit.) Ishiyaku Shuppan Ltd. Tokyo. 1979.

Maekawa R, Yamada J, Nikaido H.
Genetical studies of low plasma alkaline phosphatase (ALP) activity in the IS strain of rats.
Jikken Dobutsu. 31:13-19, 1982.

Yamada J, Nikaido H, Moritake S, Maekawa R.
Genetic analyses of the vertebral anomalies of the IS strain of rat and the development of a BN congenic line with the anomalies.
Lab Anim. 16: 40-47, 1982.

Moritake S, Yamamuro T, Yamada J, Watanabe H.
Progression of congenital kyphosis in Ishibashi rats.
Acta Orthop Scand. 54: 841-846, 1983.
Additional strain information Ishibashi rat