Strain information
 NBRP Rat No: 0259  Strain name: WF/Kop  Commmon Name: Wistar Furth Rat Genome Database
Principal Investigator:  Ichiro Semba  Kagoshima University       8-35-1, Sakuragaoka    890-8544 Kagoshima     Japan
Tel: 099-275-6142    Fax: 099-275-6148 Email: semba@dent.kagoshima-u.ac.jp
Preservation Status:   Embryo        Sperm       Living Animals ../images/Photos/WF_kop/1531a1024.jpg ../images/Photos/WF_kop/1531z1024.jpg
Coat Color  albino (c)
Inbred Generations  F103+26 (April 2012)
Usage Restrictions  In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature designated by the DEPOSITOR is requested.
Kitano, M., Hatano, H. and Shisa, H.
Strain difference of susceptibility to 4-nitroquinoline 1-oxide-induced tongue carcinoma in rats.
Jpn. J. Cancer Res. 1992, 83: 843-50.
Genetic Status
 Inbred  Segregating  Congenic  Consomic  Recombinant
 Coisogenic  Spont. Mutant  Transgene  Ind. Mutant  Category Other 
Comercial Availability
Research Category
 Diabetes Obesity  Neurobiology  Ophthalmology  Dentistry  Cardio Hypertension
 Cancer  Metabolism  Otorhinology  Immunology  Infectious
 Osteosis  Internal Organ  Dermatology  Reproduction  Development
 Behavior  Hematology  Urology  Pharmacology  Research Area Others 
 Control Strain  Marker Strain
Gene Affected
Origin J Furth established this strain from Wistar with a predilection for leukemia in 1945. Transferred to Hiroshima University, to Saitama Cancer Center in 1976, and to Kagoshima University Faculty of Dentistry in 1986. Other names are Wistar Furth and W/Fu. (Aug 17, 2010)
Strain characteristics WF rats were resistant to 4NQO-induced tongue carcinomas (Kitano, 1992; Kitano, 1996). Genetic analysis identified five significant QTLs, Tscc1, 2, 3, 4, 5 (Other names are Tcas5, 6, 2, 3, 4, respectively) (Tanuma, 1998; Tanuma, 2001). Several congenic lines carrying these QTL regions have been established (Please refer to NBRP No. 0265-0269). Class I MHC of the WF rat is RT1u. (Aug 17, 2010)
Breeding Conditions
Genotyping
References Igarashi M, Hippo Y, Ochiai M, Fukuda H, Nakagama H.
AKT is critically involved in cooperation between obesity and the dietary carcinogen amino-1-methyl-6-phenylimidazo [4,5-b] (PhIP) toward colon carcinogenesis in rats.
Biochem Biophys Res Commun. 2013 Dec 13. pii: S0006-291X(13)02128-1.

化研紀要 33:3-12, 2002

Kitano M, Hatano H, Shisa H.
Strain difference of susceptibility to 4-nitroquinoline 1-oxide-induced tongue carcinoma in rats.
Jpn J Cancer Res. 1992 Aug;83(8):843-50.

Kitano M, Hirayama Y, Tanuma J, Matsuuchi H, Miura Y, Li TJ, Semba I, Ozaki HS, Kokubu T, Hatano H, Tada M, Kobayashi Y, Shisa H.
Genetic controls of susceptibility and resistance to 4-nitroquinoline 1-oxide-induced tongue carcinomas in rats.
Jpn J Cancer Res. 87(11):1097-101, 1996.

Tanuma J, Shisa H, Hiai H, Higashi S, Yamada Y, Kamoto T, Hirayama Y, Matsuuchi H, Kitano M.
Quantitative trait loci affecting 4-nitroquinoline 1-oxide-induced tongue carcinogenesis in the rat.
Cancer Res. 15;58(8):1660-4, 1998.

Tanuma JI, Fujii K, Hirano M, Matsuuchi H, Shisa H, Hiai H, Kitano M.
Five quantitative trait loci affecting 4-nitroquinoline 1-oxide-induced tongue cancer in the rat.
Jpn J Cancer Res. 2001 Jun;92(6):610-6.
Additional strain information WF