Strain information  NBRP Rat No: 0260  Strain name: BB/OK  Commmon Name: Rat Genome Database Principal Investigator:  Ingrid Kloting  University of Greifswald       Greifswalder Str. 11    17495 Karlsburg     Germany Tel: +4938348619261    Fax: +4938348619111 Email: kloeting@uni-greifswald.de Preservation Status:   Embryo        Sperm       Living Animals Coat Color  albino (a,b,c,h) Inbred Generations  F62 Usage Restrictions  In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to the DEPOSITOR is requested. Genetic Status   Inbred  Segregating   Congenic   Consomic   Recombinant   Coisogenic   Spont. Mutant  Transgene  Ind. Mutant  Category Other  Comercial Availability Research Category   Diabetes Obesity  Neurobiology  Ophthalmology   Dentistry  Cardio Hypertension  Cancer  Metabolism  Otorhinology  Immunology  Infectious  Osteosis   Internal Organ  Dermatology   Reproduction   Development  Behavior  Hematology  Urology   Pharmacology  Research Area Others   Control Strain  Marker Strain Gene Affected Origin 1983 outbred animals from Bio Breeding Laboratories, Ottawa, Canada ---> Karlsburg,start with inbreeding Strain characteristics 80-100% of male and female BB/OK rats develop spontaneously insulin-dependent type 1 diabetes mellitus at an age of about 90 to 130days; first autoantobodies are detectable at an age of 10 days; first sign of insulitis at an age of 30 days; all animals develop insulitis up to an age of 30 weeks. Breeding Conditions Genotyping References Stark,O.,Kloting,I.,Reiher,K. and K.D. Kohnert The major histocompatibility complex and insulin-dependent diabetes in BB rats. Acta biol.med. germ.41,1982,1129-1133 Kloting, I., Hubner, R. and O. Stark Major histocompatibility complex (MHC)-independent differences between diabetes-prone BB rats and their parental Wistar rat strain in some hematologic and metabolic traits. Res. Exp. Med.182,1983,231-236 Kloting, I., O. Stark and H.J. Hahn Animal model of the insulin-dependent diabetes mellitus in BB rats: Their RT1u homogeneity and prolonged survival of allogeneic skin grafts. Folia Biol.30,1984,24-32 Kloting, I., Stark, O. and R. Brdicka Incidence of insulin-dependent diabetes mellitus in BB rats: Their genetic heterogeneity and susceptibility to infection. Folia Biol.30,1984,33-42 Kloting, I. and Stark, O. Results of the local graft-versus-host reaction support the immunogenetic concept of the insulin-dependent diabetes mellitus in BB rats. Folia Biol.30,1984,202-208 Kloting, I. und K. Reiher Einige Aspekte zur Haltung und Reproduktion spontandiabetischer BB-Ratten. Z.Versuchstierkd.27,1985,5-12 Kloting, I. and O. Stark Occurrence of antibodies against gene products of the major histocompatibility complex in normal sera of diabetes-prone BB rats. Folia Biol.31,1985,34-37 Kloting, I. and O. Stark Genetic studies of IDDM in BB rats: The incidence of diabetes in F2 and first backcross hybrids allows rejection of recessive hypothesis. Exp.Clin.Endocrinol.89,1987,312-318 Kloting, I., Vogt, L., Stark, O.and U. Fischer Genetic heterogeneity in different BB rat subpopulations. Diabetes Res.6,1987,145-149 Knospe, S., Kohler, E. and I. Kloting Cell-mediated immune reactions against islets of Langerhans in diabetes-prone BB rats. Exp.Clin.Endocrinol.89,1987,290-296 Ziegler, B., Kloting, I., Besch, W., Ziegler, M. and H.J. Hahn Cytotoxic activity of sera from diabetic BB rats against BB rat islet-a functional study. Diabetes Res. 4,1987,67-72 Kloting, I. and L. Vogt Breeding problems in diabetes-prone BB rats after "wet hysterectomy". Z.Versuchstierkd.31, 1988,19-22 Hehmke, B., Schröder, D. and I. Kloting Early appearance of complement-dependent antibody-mediated cytotoxicity (C , AMC) to islet cells in serum of diabetes-prone BB/OK rats. Diabetes Res.15,1990,183-186 Vogt, L. and I. Kloting Breeding management of BB rats by the aid of the computer program BB_RADABA. J.Exp.Anim.Sci.35,1992,34,184-188 Kloting, I. and L. Vogt BB/O(ttawa)K (arlsburg) rats: Features of a subline of diabetes-prone BB rats.Diabetes Res., 1991,18,79-87 Dunger, A., Kloting, I., Besch, W. and H.J. Hahn The effect of serum concentration and sources on DNA synthesis and insulin secretion of cultured islets. Exp.Clin.Endocrinol.99, 1992, 34-38 Kloting, I. and L. Vogt On the influence of metabolic state of parents at conception and pregnancy on incidence and age at onset of diabetes in the progeny of BB/OK rats. Diabetes Res. 19,1992, 37-40 Kloting, I., Voigt B. and L. Vogt Molecular analysis of diabetes-prone BB rat sublines and derivatives of their common ancestor as a tool to search for candidate loci causing different phenotypes in BB rats. Diabetes Res. 29, 1995, 65-71 Lucke, S., Kloting, I., Pusch, A., Heinrich, H.W. and H.J. Hahn Endocrine pancreas histology of congenic BB-Rat strains with reduced diabetes incidence after genetic manipulation on chromosomes 4, 6 and X. Autoimmunity 36, 2003, 143-149 Hahn, H.J., Lucke, S., Kloting, I. and W. Besch Prospective investigations of long-term normoglycaemic BB/OK-rats: Serial determination of glucose tolerance, insulitis, B-cell volume density and pancreatic insulin content. Exp.Clin.Endocrinol.98, 1991, 185-192 Additional strain information BB