Strain information
 NBRP Rat No: 0264  Strain name: WOKW/K  Commmon Name: WOKW Rat Genome Database
Principal Investigator:  Ingrid Kloting  University of Greifswald       Greifswalder Str. 11    17495 Karlsburg     Germany
Tel: +4938348619261    Fax: +4938348619111 Email: kloeting@uni-greifswald.de
Preservation Status:   Embryo        Sperm       Living Animals
Coat Color  albino (a,b,c,h)
Inbred Generations  F68
Usage Restrictions  In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to the DEPOSITOR is requested.
Genetic Status
 Inbred  Segregating  Congenic  Consomic  Recombinant
 Coisogenic  Spont. Mutant  Genetically Modified (GM)  Ind. Mutant  Category Other 
Comercial Availability
Research Category
 Diabetes Obesity  Neurobiology  Ophthalmology  Dentistry  Cardio Hypertension
 Cancer  Metabolism  Otorhinology  Immunology  Infectious
 Osteosis  Internal Organ  Dermatology  Reproduction  Development
 Behavior  Hematology  Urology  Pharmacology  Research Area Others 
 Control Strain  Marker Strain
Gene Affected
Origin Outbred Wistar rats were transferred from the BioBreeding Laboratories in Ottawa, Canada, to the Institute of Pathophysiology (formerly the Institute of Diabetes Gerhardt Katsch) in Karlsburg, Germany in 1981. By selective breeding of RT1a or RT1u homozygous from the outbred Wistar rats, two inbred lines were generated as WOK.1A (Wistar Ottawa Karlsburg RT1a) or WOK.1W respectively (Kovács, 1997). Wistar Ottawa Karlsburg W. (Sep 16, 2010)
Strain characteristics WOKW rats and BB/OK rats were originated from the same colony of Wistar rat and both strains possess RT1u haplotype (Kovács, 1997). WOKW rats develop polygenic inherited metabolic syndrome resembling human disorder such as obesity, dyslipidemia, impaired glucose tolerance (IGT), hyperinsulinemia and hyperleptinemia (Kovács, 1997; Kovács, 2000; van den Brandt, 2000; van den Brandt, 2002). By breeding analysis of disease-prone WOKW and disease-resistant DA rats, several QTLs associated with metabolic syndrome were mapped (Kovács, 2000; Klöting, 2001; Baguhl, 2009). Some of them were sex-specific. (Sep 16, 2010)
Breeding Conditions
Genotyping
References Kloting I, Voigt B. and L Vogt.
Molecular analysis of diabetes-prone BB rat sublines and derivatives of their common ancestor as a tool to search for candidate loci causing different phenotypes in BB rats.
Diabetes Res. 29, 65-71, 1995.

Kovács P, van den Brandt J, Klöting I.
Genetic dissection of the syndrome X in the rat.
Biochem Biophys Res Commun. 269(3):660-5, 2000.

van den Brandt J, Kovács P, Klöting I.
Features of the metabolic syndrome in the spontaneously hypertriglyceridemic Wistar Ottawa Karlsburg W (RT1u haplotype) rat.
Metabolism. 2000 Sep;49(9):1140-4.

van den Brandt J, Kovacs P, Klöting I.
Metabolic syndrome and aging in Wistar Ottawa Karlsburg W rats.
Int J Obes Relat Metab Disord. 2002 Apr;26(4):573-6.

Klöting I, Kovács P, van den Brandt J.
Sex-specific and sex-independent quantitative trait loci for facets of the metabolic syndrome in WOKW rats.
Biochem Biophys Res Commun. 2001 Jun 1;284(1):150-6.

Schreyer S, Ledwig D, Rakatzi I, Klöting I, Eckel J.
Insulin receptor substrate-4 is expressed in muscle tissue without acting as a substrate for the insulin receptor.
Endocrinology. 144(4):1211-8, 2003.

Kovács P, Voigt B, Berg S, Vogt L, Klöting I.
WOK.1W rats. A potential animal model of the insulin resistance syndrome.
Ann N Y Acad Sci. 20;827:94-9, 1997.

Baguhl R, Wilke B, Klöting N, Klöting I.
Genes on rat chromosomes 3, 5, 10, and 16 are linked with facets of metabolic syndrome.
Obesity (Silver Spring). 2009 Jun;17(6):1215-9. Epub 2009 Feb 19.
Additional strain information