Strain information
 NBRP Rat No: 0261  Strain name: BB.SHR-(D4Got41-Tacr1)/K  Commmon Name: BB.SHR-(D4Got41-Tacr1) Rat Genome Database
Principal Investigator:  Ingrid Kloting  University of Greifswald       Greifswalder Str. 11    17495 Karlsburg     Germany
Tel: +4938348619261    Fax: +4938348619111 Email: kloeting@uni-greifswald.de
Preservation Status:   Embryo        Sperm       Living Animals
Coat Color  albino (a,b,c,h)
Inbred Generations  N5F12
Usage Restrictions  In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to the DEPOSITOR is requested.
Genetic Status
 Inbred  Segregating  Congenic  Consomic  Recombinant
 Coisogenic  Spont. Mutant  Transgene  Ind. Mutant  Category Other 
Comercial Availability
Research Category
 Diabetes Obesity  Neurobiology  Ophthalmology  Dentistry  Cardio Hypertension
 Cancer  Metabolism  Otorhinology  Immunology  Infectious
 Osteosis  Internal Organ  Dermatology  Reproduction  Development
 Behavior  Hematology  Urology  Pharmacology  Research Area Others 
 Control Strain  Marker Strain
Gene Affected
Origin Congenic BB.LL rats were established as speed-congenics by cross of BB/OK and SHR/Mol rats and repeated backcrossing onto BB/OK rats and marker-aided selection in 1997.
Strain characteristics Animals are not hypertensive, but develop an incomplete metabolic syndrome with obesity, hyperleptinemia and dyslipidemia. About 70% of animals are prone to apoplectic stroke.
Breeding Conditions
Genotyping
References Kloting I, Kovacs P, Kuttler B.
Phenotypic consequences after restoration of lymphopenia in the diabetes-prone BB/OK rat.
Biochem Biophys Res Commun. 1997 Oct 9;239(1):106-10.

Kovacs P, van den Brandt J, Bonne AC, van Zutphen LF, van Lith HA, Kloting I.
Congenic BB.SHR rat provides evidence for effects of a chromosome 4 segment (D4Mit6-Npy approximately 1 cm) on total serum and lipoprotein lipid concentration and composition after feeding a high-fat, high-cholesterol diet.
Metabolism. 2001 50(4):458-62.

Kloting I, Kovacs P. and van den BrandtJ
Congenic BB.SHR (D4Mit6-Npy-Spr) rats: A new aid to dissect the genetics of obesity.
Obes Res. 2002 10(10):1074-7.

Lucke S, Kloting I, Pusch A, Heinrich HW and Hahn HJ
Endocrine pancreas histology of congenic BB-Rat strains with reduced diabetes incidence after genetic manipulation on chromosomes 4, 6 and X.
Autoimmunity. 2003 36(3):143-9.
Additional strain information BB SHR