NBRP Rat No: 0262
Commmon Name: BB.SHR-(
Rat Genome Database
Ingrid Kloting University of Greifswald Greifswalder Str. 11 17495 Karlsburg Germany
Tel: +4938348619261 Fax: +4938348619111
In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to the DEPOSITOR is requested.
Genetically Modified (GM)
Research Area Others
Congenic BB.6S rats were established by cross of BB/OK and SHR/Mol rats and repeated backcrossing onto BB/OK rats in 2000.
Diabetes frequency is significantly decreased in comparison with parental BB/OK rats (15 vs. 86%).Animals are heavier and serum lipids are increased compared with BB/OK.
Kloting I, Schmidt S, Kovacs P.
Mapping of novel genes predisposing or protecting diabetes development in the BB/OK rat.
Biochem Biophys Res Commun. 1998 Apr 17;245(2):483-6.
Kloting I, Van Den Brandt J, Kovács P.
Quantitative trait loci for blood glucose confirm diabetes predisposing and protective genes, Iddm4 and Iddm5r, in the spontaneously diabetic BB/OK rat.
Int J Mol Med. 1998 Nov;2(5):597-601.
Kloting I, van den Brandt J, Kuttler B.
Genes of SHR rats protect spontaneously diabetic BB/OK rats from diabetes: lessons from congenic BB.SHR rat strains.
Biochem Biophys Res Commun. 2001 May 4;283(2):399-405.
Additional strain information