| NBRP Rat No: 0262 |
Strain name: BB.SHR-(D6Rat184-D6Rat3)/K |
Commmon Name: BB.SHR-(D6Rat184-D6Rat3) |
Rat Genome Database |
| Principal Investigator: |
Ingrid Kloting University of Greifswald Greifswalder Str. 11 17495 Karlsburg Germany |
| Tel: +4938348619261 Fax: +4938348619111 |
Email: kloeting@uni-greifswald.de |
| Preservation Status: |
Embryo Sperm Living Animals |
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| Coat Color |
albino (a,b,c,h) |
| Inbred Generations |
N8F8 |
| Usage Restrictions |
In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to the DEPOSITOR is requested. |
| Genetic Status |
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| Comercial Availability |
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| Research Category |
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| Gene Affected |
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| Origin |
Congenic BB.6S rats were established by cross of BB/OK and SHR/Mol rats and repeated backcrossing onto BB/OK rats in 2000.
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| Strain characteristics |
Diabetes frequency is significantly decreased in comparison with parental BB/OK rats
(15 vs. 86%).Animals are heavier and serum lipids are increased compared with BB/OK. |
| Breeding Conditions |
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| Genotyping |
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| References |
Kloting I, Schmidt S, Kovacs P.
Mapping of novel genes predisposing or protecting diabetes development in the BB/OK rat.
Biochem Biophys Res Commun. 1998 Apr 17;245(2):483-6.
Kloting I, Van Den Brandt J, Kovács P.
Quantitative trait loci for blood glucose confirm diabetes predisposing and protective genes, Iddm4 and Iddm5r, in the spontaneously diabetic BB/OK rat.
Int J Mol Med. 1998 Nov;2(5):597-601.
Kloting I, van den Brandt J, Kuttler B.
Genes of SHR rats protect spontaneously diabetic BB/OK rats from diabetes: lessons from congenic BB.SHR rat strains.
Biochem Biophys Res Commun. 2001 May 4;283(2):399-405. |
| Additional strain information |
BB SHR |
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