Usage Restrictions
The users should offer a collaboration study plan to Department of Oral Pathology, Kagoshima University Graduate School of Medical and Dental Sciences.
Gene Affected
Tscc1 (Tongue tumor susceptibility QTL 1, alias Tcas5), Tscc4 (Tcas3), Tscc2 (Tcas6)
Origin
DA rats are highly susceptible to 4NQO-induced tongue carcinoma, whereas WF rats are barely susceptible (Kitano, 1992). To establish this congenic strain, QTL region Tscc1 (Tongue squamous cell carcinoma 1, alias Tcas5 RGD: 724565), Tscc4 (alias Tcas3 RGD: 631261), Tscc2 (alias Tcas6 RGD: 724567) were introgressed from WF rat to DA rat background (Tanuma, 1998; Tanuma, 2001). (Aug 20, 2010)
References
Kitano M, Hatano H, Shisa H.
Strain difference of susceptibility to 4-nitroquinoline 1-oxide-induced tongue carcinoma in rats.
Jpn J Cancer Res. 1992 Aug;83(8):843-50.
Tanuma J, Shisa H, Hiai H, Higashi S, Yamada Y, Kamoto T, Hirayama Y, Matsuuchi H, Kitano M.
Quantitative trait loci affecting 4-nitroquinoline 1-oxide-induced tongue carcinogenesis in the rat.
Cancer Res. 15;58(8):1660-4, 1998.
Tanuma JI, Fujii K, Hirano M, Matsuuchi H, Shisa H, Hiai H, Kitano M.
Five quantitative trait loci affecting 4-nitroquinoline 1-oxide-induced tongue cancer in the rat.
Jpn J Cancer Res. 2001 Jun;92(6):610-6.