Strain information
 NBRP Rat No: 0268  Strain name: DA.WF-(D4Mit11-Nos3)/Kop  Commmon Name: DA.WF-Tcas3/Kop, DA.WF-Tscc4, DWTscc4 Rat Genome Database
Principal Investigator:  Ichiro Semba  Kagoshima University       8-35-1, Sakuragaoka    890-8544 Kagoshima     Japan
Tel: 099-275-6142    Fax: 099-275-6148 Email: semba@dent.kagoshima-u.ac.jp
Preservation Status:   Embryo        Sperm       Living Animals
Coat Color  agouti
Inbred Generations  N6F20
Usage Restrictions  The users should offer a collaboration study plan to Department of Oral Pathology, Kagoshima University Graduate School of Medical and Dental Sciences.
Genetic Status
 Inbred  Segregating  Congenic  Consomic  Recombinant
 Coisogenic  Spont. Mutant  Transgene  Ind. Mutant  Category Other 
Comercial Availability
Research Category
 Diabetes Obesity  Neurobiology  Ophthalmology  Dentistry  Cardio Hypertension
 Cancer  Metabolism  Otorhinology  Immunology  Infectious
 Osteosis  Internal Organ  Dermatology  Reproduction  Development
 Behavior  Hematology  Urology  Pharmacology  Research Area Others 
 Control Strain  Marker Strain
Gene Affected Tscc4 (Tongue tumor susceptibility QTL 4, alias Tcas3)
Origin DA rats are highly susceptible to 4NQO-induced tongue carcinoma, whereas WF rats are barely susceptible (Kitano, 1992). To establish this congenic strain, QTL region Tscc4 (Tongue squamous cell carcinoma 4, alias Tcas3 RGD: 631261) were introgressed from WF rat to DA rat background (Tanuma, 1998; Tanuma, 2001). (Aug 20, 2010)
Strain characteristics
Breeding Conditions Sib mating.
Genotyping
References Kitano M, Hatano H, Shisa H.
Strain difference of susceptibility to 4-nitroquinoline 1-oxide-induced tongue carcinoma in rats.
Jpn J Cancer Res. 1992 Aug;83(8):843-50.

Tanuma J, Shisa H, Hiai H, Higashi S, Yamada Y, Kamoto T, Hirayama Y, Matsuuchi H, Kitano M.
Quantitative trait loci affecting 4-nitroquinoline 1-oxide-induced tongue carcinogenesis in the rat.
Cancer Res. 15;58(8):1660-4, 1998.

Tanuma JI, Fujii K, Hirano M, Matsuuchi H, Shisa H, Hiai H, Kitano M.
Five quantitative trait loci affecting 4-nitroquinoline 1-oxide-induced tongue cancer in the rat.
Jpn J Cancer Res. 2001 Jun;92(6):610-6.

Suwa H, Hirano M, Kawarada K, Nagayama M, Ehara M, Muraki T, Shisa H, Sugiyama A, Sugimoto M, Hiai H, Kitano M, Tanuma J.
Pthlh, a promising cancer modifier gene in rat tongue carcinogenesis.
Oncol Rep. 2014 Jan;31(1):3-12. doi: 10.3892/or.2013.2859.
Additional strain information DA WF