Strain information
 NBRP Rat No: 0276  Strain name: W-Tg(CAG-ABO*B)13Jmsk  Commmon Name: Wistar-Tg(CAG-ABO*B)13Jmsk, Wistar-Tg(CAG-TfB)13Jmsk, B13 Rat Genome Database
Principal Investigator:  Eiji Kobayashi  Center for Molecular Medicine, Jichi Medical School       3311-1, Yakushiji, Shimono-shi, Tochigi    329-0498 Tochigi     Japan
Tel: 0285-58-7446    Fax: 0285-44-5365 Email: eijikoba@jichi.ac.jp
Preservation Status:   Embryo        Sperm       Living Animals
Coat Color  albino (c)
Inbred Generations  
Usage Restrictions  The recipient is requested to cite in the following literature designated by the DEPOSITOR.
Genetic Status
 Inbred  Segregating  Congenic  Consomic  Recombinant
 Coisogenic  Spont. Mutant  Transgene  Ind. Mutant  Category Other 
Comercial Availability
Research Category
 Diabetes Obesity  Neurobiology  Ophthalmology  Dentistry  Cardio Hypertension
 Cancer  Metabolism  Otorhinology  Immunology  Infectious
 Osteosis  Internal Organ  Dermatology  Reproduction  Development
 Behavior  Hematology  Urology  Pharmacology  Research Area Others 
 Control Strain  Marker Strain
Gene Affected ABO: ABO blood group (transferase A, alpha 1-3-N-acetylgalactosaminyltransferase; transferase B, alpha 1-3-galactosyltransferase)
Origin This strain was established at Jichi Medical School.
Strain characteristics This transgenic strain expresses the transferase B of the ABO blood group (transferase A, alpha 1-3-N-acetylgalactosaminyltransferase ) driven by the CAG promoter. The majority of expression of the transgene is detected in the small intestinal mucosa. The transgene was found to have integrated into the Chr X.
Breeding Conditions Good breeding performance.
Genotyping
References Iwamoto S, Kumada M, Kamesaki T, Okuda H, Kajii E, Inagaki T, Saikawa D, Takeuchi K, Ohkawara S, Takahashi R, Ueda S, Inoue S, Tahara K, Hakamata Y, Kobayashi E.
Rat encodes the paralogous gene equivalent of the human histo-blood group ABO gene. Association with antigen expression by overexpression of human ABO transferase.
J Biol Chem. 29;277(48):46463-9, 2002.
Additional strain information Wistar