Origin
This strain is originated from Fischer344 which transferred from Dr. Dunning to Charles River Laboratories, Inc., 1960 at F68. Breeding under SPF condition has started in 1965 at F81 and F110 rats were transferred to Charles River Japan, Inc. in 1976. (May 27, 2010)
Strain characteristics
Small size, docile. (May 27, 2010)
This strain has a missense mutation (Gly633Arg) in DIPEPTIDYL PEPTIDASE IV（Dpp4）gene. The functional DPP4 protein is not expressed in this strain. (July 7, 2016).
Breeding Conditions
Good breeding performance. (May 27, 2010)
References
Kim H, Yoshihara M, Suyama M.
Comparative genomic analysis of inbred rat strains reveals the existence of ancestral polymorphisms.
Mamm Genome. 2020 Apr;31(3-4):86-94.
Yoshihara M, Sato T, Saito D, Ohara O, Kuramoto T, Suyama M.
Application of target capture sequencing of exons and conserved non-coding sequences to 20 inbred rat strains.
Genomics Data. 2016 Dec; 10: 155-157
Nakanishi S, Serikawa T, Kuramoto T.
Slc:Wistar Outbred Rats Show Close Genetic Similarity with F344 Inbred Rats.
Exp Anim. 64(1):25-29, 2015.
Biochemistry. 1992 Dec 1;31(47):11921-7.
An active-site mutation (Gly633-->Arg) of dipeptidyl peptidase IV causes its retention and rapid degradation in the endoplasmic reticulum.
Tsuji E1, Misumi Y, Fujiwara T, Takami N, Ogata S, Ikehara Y.