Strain information
 NBRP Rat No: 0506  Strain name: F344/DuCrlCrlj  Commmon Name: Rat Genome Database
Principal Investigator:  Shinya Takahashi  Charles river laboratories Japan       11F 3-17-16 Shinyokohama, Kouhokuku, Yokohama    222-0033 Kanagawa     Japan
Tel: 045(474)9340     Fax: 045(474)9341 Email:
Preservation Status:   Embryo        Sperm       Living Animals ../images/Photos/F344_DuCrlCrlj/1101a1024.jpg ../images/Photos/F344_DuCrlCrlj/1101z1024.jpg
Coat Color  albino (c)
Inbred Generations  
Usage Restrictions  
Genetic Status
 Inbred  Segregating  Congenic  Consomic  Recombinant
 Coisogenic  Spont. Mutant  Transgene  Ind. Mutant  Category Other 
Comercial Availability
Research Category
 Diabetes Obesity  Neurobiology  Ophthalmology  Dentistry  Cardio Hypertension
 Cancer  Metabolism  Otorhinology  Immunology  Infectious
 Osteosis  Internal Organ  Dermatology  Reproduction  Development
 Behavior  Hematology  Urology  Pharmacology  Research Area Others 
 Control Strain  Marker Strain
Gene Affected
Origin This strain is originated from Fischer344 which transferred from Dr. Dunning to Charles River Laboratories, Inc., 1960 at F68. Breeding under SPF condition has started in 1965 at F81 and F110 rats were transferred to Charles River Japan, Inc. in 1976. (May 27, 2010)
Strain characteristics Small size, docile. (May 27, 2010)
This strain has a missense mutation (Gly633Arg) in DIPEPTIDYL PEPTIDASE IV(Dpp4)gene. The functional DPP4 protein is not expressed in this strain. (July 7, 2016).
Breeding Conditions Good breeding performance. (May 27, 2010)
References Yoshihara M, Sato T, Saito D, Ohara O, Kuramoto T, Suyama M.
Application of target capture sequencing of exons and conserved non-coding sequences to 20 inbred rat strains.
Genomics Data. 2016 Dec; 10: 155-157

Nakanishi S, Serikawa T, Kuramoto T.
Slc:Wistar Outbred Rats Show Close Genetic Similarity with F344 Inbred Rats.
Exp Anim. 64(1):25-29, 2015.

Biochemistry. 1992 Dec 1;31(47):11921-7.
An active-site mutation (Gly633-->Arg) of dipeptidyl peptidase IV causes its retention and rapid degradation in the endoplasmic reticulum.
Tsuji E1, Misumi Y, Fujiwara T, Takami N, Ogata S, Ikehara Y.
Additional strain information