| NBRP Rat No: 0506 |
Strain name: F344/DuCrlCrlj |
Commmon Name: |
Rat Genome Database |
| Principal Investigator: |
Shinya Takahashi Charles river laboratories Japan 11F 3-17-16 Shinyokohama, Kouhokuku, Yokohama 222-0033 Kanagawa Japan |
| Tel: 045（474）9340 Fax: 045（474）9341 |
Email: web_order@jp.crl.com |
| Preservation Status: |
Embryo Sperm Living Animals |
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| Coat Color |
albino (c) |
| Inbred Generations |
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| Usage Restrictions |
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| Genetic Status |
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| Comercial Availability |
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| Research Category |
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| Gene Affected |
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| Origin |
This strain is originated from Fischer344 which transferred from Dr. Dunning to Charles River Laboratories, Inc., 1960 at F68. Breeding under SPF condition has started in 1965 at F81 and F110 rats were transferred to Charles River Japan, Inc. in 1976. (May 27, 2010) |
| Strain characteristics |
Small size, docile. (May 27, 2010)
This strain has a missense mutation (Gly633Arg) in DIPEPTIDYL PEPTIDASE IV（Dpp4）gene. The functional DPP4 protein is not expressed in this strain. (July 7, 2016).
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| Breeding Conditions |
Good breeding performance. (May 27, 2010) |
| Genotyping |
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| References |
Yoshihara M, Sato T, Saito D, Ohara O, Kuramoto T, Suyama M.
Application of target capture sequencing of exons and conserved non-coding sequences to 20 inbred rat strains.
Genomics Data. 2016 Dec; 10: 155-157
Nakanishi S, Serikawa T, Kuramoto T.
Slc:Wistar Outbred Rats Show Close Genetic Similarity with F344 Inbred Rats.
Exp Anim. 64(1):25-29, 2015.
Biochemistry. 1992 Dec 1;31(47):11921-7.
An active-site mutation (Gly633-->Arg) of dipeptidyl peptidase IV causes its retention and rapid degradation in the endoplasmic reticulum.
Tsuji E1, Misumi Y, Fujiwara T, Takami N, Ogata S, Ikehara Y. |
| Additional strain information |
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