Strain information  NBRP Rat No: 0287  Strain name: WTC-swh/Kyo  Commmon Name: WTC-swh Rat Genome Database Principal Investigator:  Takashi Kuramoto  Graduate School of Medicine, Kyoto University       Yoshidakonoe-cho, Sakyo-ku    606-8501 Kyoto     Japan Tel: 075-753-4494    Fax: 075-753-4409 Email: kuramot@anim.med.kyoto-u.ac.jp Preservation Status:   Embryo        Sperm       Living Animals Coat Color  albino (c) Inbred Generations  F37 (March 2012) Usage Restrictions  The recipient of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR. For a commercial use of this resource, a new contract must be concluded between the depositor and the recipient. Genetic Status   Inbred  Segregating   Congenic   Consomic   Recombinant   Coisogenic   Spont. Mutant  Transgene  Ind. Mutant  Category Other  Comercial Availability Research Category   Diabetes Obesity  Neurobiology  Ophthalmology   Dentistry  Cardio Hypertension  Cancer  Metabolism  Otorhinology  Immunology  Infectious  Osteosis   Internal Organ  Dermatology   Reproduction   Development  Behavior  Hematology  Urology   Pharmacology  Research Area Others   Control Strain  Marker Strain Gene Affected Origin The rat showed abnormal hair texture and mammary gland hypoplasia was occurred in the WTC.ZI-Atrnzi colony at the National Cancer Center Research Institute in 1998. After elimination of zi allele, this strain has been maintained by sib mating and transferred to Kyoto Univ. in April 2002. Strain characteristics Homozygous mutants show sparse fur, which is most prominent at 3–4 weeks of age, and small body size. Swh (Sparse and wavy) locus was mapped on Chr 17.　In 2011, Kuramoto et al. identified a missense mutation in the Edaradd gene. Breeding Conditions Both male and female homozygous rats are fertile but female homozygous rat cannnot take care of their pups well. Therefore heterozygous female and homozygous male are mated. Genotyping References Del-Pozo J, Headon DJ, Glover JD, Azar A, Schuepbach-Mallepell S, Bhutta MF, Riddell J, Maxwell S, Milne E, Schneider P, Cheeseman M. The EDA-deficient mouse has Zymbal's gland hypoplasia and acute otitis externa. Dis Model Mech. 2022 Mar 1;15(3):dmm049034. Del-Pozo J, MacIntyre N, Azar A, Headon D, Schneider P, Cheeseman M. Role of ectodysplasin signalling in middle ear and nasal pathology in rat and mouse models of hypohidrotic ectodermal dysplasia. Dis Model Mech. 2019 Apr 25;12(4):dmm037804. Yoshihara M, Saito D, Sato T, Ohara O, Kuramoto T, Suyama M. Design and application of a target capture sequencing of exons and conserved non-coding sequences for the rat. BMC Genomics. 2016 Aug 9;17:593. Kuramoto T, Yokoe M, Hashimoto R, Hiai H, Serikawa T. A rat model of hypohidrotic ectodermal dysplasia carries a missense mutation in the Edaradd gene. BMC Genetics 12:91, 2011 Kuramoto T, Morimura K, Nomoto T, Namiki C, Hamada S, Fukushima S, Sugimura T, Serikawa T, Ushijima T. Sparse and wavy hair: a new model for hypoplasia of hair follicle and mammary glands on rat chromosome 17. J Hered. 2005 Jul-Aug;96(4):339-45. Additional strain information WTC