Strain information  NBRP Rat No:   Strain name: HOB (hob/+)  Commmon Name: hobble rat Principal Investigator:  Yosuke Ando  DAIICHI SANKYO Co., Ltd.       717, Horikoshi, Fukuroi-shi    437-0065 Shizuoka     JAPAN Tel: 0538-42-4356    Fax: 0538-42-4350 Email: ando.yosuke.x8@daiichisankyo.co.jp Preservation Status:   Embryo        Sperm       Living Animals Coat Color  a,B,C,h Inbred Generations  F13+12 Usage Restrictions  The recipient of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR. Genetic Status   Inbred  Segregating   Congenic   Consomic   Recombinant   Coisogenic   Spont. Mutant  Transgene  Ind. Mutant  Category Other  Comercial Availability Research Category   Diabetes Obesity  Neurobiology  Ophthalmology   Dentistry  Cardio Hypertension  Cancer  Metabolism  Otorhinology  Immunology  Infectious  Osteosis   Internal Organ  Dermatology   Reproduction   Development  Behavior  Hematology  Urology   Pharmacology  Research Area Others   Control Strain  Marker Strain Gene Affected Origin HOB rat was identified in the F344 congenic rats (N12F13) to which the coat color locus (C) of fatty rat has been transferred in Sankyo Co., Ltd. Introduced to Kyoto University in 1999 at F13. Strain characteristics Abnormal behavior with a swaying gait due to hind-leg paralysis is observed at 2-3 weeks after birth. Reproductivity of affected (hob/hob) males is extremely low. Pathological examination on the cerebellum shows flat shape, vermis defect, partially invaginated molecular layer, and ectopic Purkinje cells. The hob is allelic to the cvd on the Unc5h3 locus. Breeding Conditions Maintained by brather-sister matings between hob/+ males and hob/hob females. Good breeding performance. Genotyping PCR-RFLP（see Kuramoto et al. Mol. Brain Res. 122(2): 103-108, 2004) References 第44回日本実験動物学会総会　講演要旨集P145　1997大宮市 Kuwamura, M., Ando, Y., Takeda, A., Kanehara, T., Yamane, J., Kotani, T., Takeshita, S., Kanbori, M., Kitada, K., Serikawa, T. Rat mutations cvd and hob with cerebellar malformations map to chromosome 2. Exp. Anim. 53(1): 21-26, 2004. Kuramoto, T., Kuwamura, M., Serikawa, T. Rat neurological mutations cerebellar vermis defect and hobble are caused by mutations in the netrin-1 receptor gene Unc5h3. Mol. Brain Res. 122(2): 103-108, 2004. Additional strain information HOB