Usage Restrictions
The recipient of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR.
Origin
HOB rat was identified in the F344 congenic rats (N12F13) to which the coat color locus (C) of fatty rat has been transferred in Sankyo Co., Ltd. Introduced to Kyoto University in 1999 at F13.
Strain characteristics
Abnormal behavior with a swaying gait due to hind-leg paralysis is observed at 2-3 weeks after birth. Reproductivity of affected (hob/hob) males is extremely low. Pathological examination on the cerebellum shows flat shape, vermis defect, partially invaginated molecular layer, and ectopic Purkinje cells. The hob is allelic to the cvd on the Unc5h3 locus.
Breeding Conditions
Maintained by brather-sister matings between hob/+ males and hob/hob females. Good breeding performance.
Genotyping
PCR-RFLP（see Kuramoto et al. Mol. Brain Res. 122(2): 103-108, 2004)
References
第44回日本実験動物学会総会 講演要旨集P145 1997大宮市
Kuwamura, M., Ando, Y., Takeda, A., Kanehara, T., Yamane, J., Kotani, T., Takeshita, S., Kanbori, M., Kitada, K., Serikawa, T.
Rat mutations cvd and hob with cerebellar malformations map to chromosome 2.
Exp. Anim. 53(1): 21-26, 2004.
Kuramoto, T., Kuwamura, M., Serikawa, T.
Rat neurological mutations cerebellar vermis defect and hobble are caused by mutations in the netrin-1 receptor gene Unc5h3.
Mol. Brain Res. 122(2): 103-108, 2004.