| NBRP Rat No: 0285 |
Strain name: GAERS/Mave |
Commmon Name: GAERS, Genetic Absence Epilepsy Rats from Strasbourg |
Rat Genome Database |
| Principal Investigator: |
Astrid Nehlig Universite Louis Pasteur 11 rue Hunmann 67085 Strasbourg France |
| Tel: +33 390 24 32 43 Fax: +33 390 24 32 56 |
Email: nehlig@neurochem.u-strasbg.fr |
| Preservation Status: |
Embryo Sperm Living Animals |
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| Coat Color |
albino (c) |
| Inbred Generations |
F61+19 (Jun 2010) |
| Usage Restrictions |
In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature designated by the DEPOSITOR is requested.
Danober L., Deransart C., Depaulis A., Vergnes M., Marescaux C. Pathophysiological mechanisms of genetic absence epilepsy in the rat. Prog. Neurobiol. 1998 May; 55 (1): 27-57. |
| Genetic Status |
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| Comercial Availability |
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| Research Category |
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| Gene Affected |
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| Origin |
Thirty per cent of the Wistar rats from the initial breeding colony in their laboratory in Strasbourg presented spontaneous spike and wave discharges (SWDs) which were bilateral and synchronous over the cerebral cortex. A strain in which all animals displayed SWDs was selected after several generations by selecting breeders with SWDs. |
| Strain characteristics |
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| Breeding Conditions |
Good breeding performance. |
| Genotyping |
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| References |
Miyamoto H, Tatsukawa T, Shimohata A, Yamagata T, Suzuki T, Amano K, Mazaki E, Raveau M, Ogiwara I, Oba-Asaka A, Hensch TK, Itohara S, Sakimura K, Kobayashi K, Kobayashi K, Yamakawa K.
Impaired cortico-striatal excitatory transmission triggers epilepsy.
Nat Commun. 2019 Apr 23;10(1):1917.
Danober L, Deransart C, Depaulis A, Vergnes M, Marescaux C.
Pathophysiological mechanisms of genetic absence epilepsy in the rat.
Prog Neurobiol. 55(1):27-57, 1998.
Rudolf G, Thérèse Bihoreau M, F Godfrey R, P Wilder S, D Cox R, Lathrop M, Marescaux C, Gauguier D.
Polygenic control of idiopathic generalized epilepsy phenotypes in the genetic absence rats from Strasbourg (GAERS).
Epilepsia. 45(4):301-8, 2004.
Powell KL, Cain SM, Ng C, Sirdesai S, David LS, Kyi M, Garcia E, Tyson JR, Reid CA, Bahlo M, Foote SJ, Snutch TP, O'Brien TJ.
A Cav3.2 T-type calcium channel point mutation has splice-variant-specific effects on function and segregates with seizure expression in a polygenic rat model of absence epilepsy.
J Neurosci. 2009 Jan 14;29(2):371-80.
Mohammad Rafiqul ISLAM, Jafri Malin ABDULLAH
Age-dependent Electroencephalographic Differences in the Genetic Absence Epilepsy Rats from Strasbourg (GAERS) Model of Absence Epilepsy.
Malays J Med Sci. 2014 Dec; 21(Spec Issue): 34–40.
Serikawa T, Mashimo T, Kuramoto T, Voigt B, Ohno Y, Sasa M.
Advances on Genetic Rat Models of Epilepsy.
Exp Anim. 64(1):1-7, 2015. |
| Additional strain information |
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