Strain information
 NBRP Rat No: 0378  Strain name: WKY/Ezo  Commmon Name: Rat Genome Database
Principal Investigator:  Hiroko Togashi  Health Sciences University of Hokkaido       1757 Kanazawa, Tobetsu-cho, Ishikari-gun    061-0293 Hokkaido     Japan
Tel: 0133-23-1211    Fax: 0133-23-1849 Email: hirot@hoku-iryo-u.ac.jp
Preservation Status:   Embryo        Sperm       Living Animals ../images/Photos/WKY_Ezo/1721a1024.jpg ../images/Photos/WKY_Ezo/1721z1024.jpg
Coat Color  albino (c)
Inbred Generations  
Usage Restrictions  In publishing, a citation of the following literature(s) designated by the DEPOSITOR is requested.
In publishing, an acknowledgment to the DEPOSITOR is requested.
The recipient of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR.

For a breeding use, a new contract must be concluded between the DEPOSITOR and the recipient.
After finishing the defined period in the contract, the recipient requires immediate stop of breeding.
Genetic Status
 Inbred  Segregating  Congenic  Consomic  Recombinant
 Coisogenic  Spont. Mutant  Transgene  Ind. Mutant  Category Other 
Comercial Availability
Research Category
 Diabetes Obesity  Neurobiology  Ophthalmology  Dentistry  Cardio Hypertension
 Cancer  Metabolism  Otorhinology  Immunology  Infectious
 Osteosis  Internal Organ  Dermatology  Reproduction  Development
 Behavior  Hematology  Urology  Pharmacology  Research Area Others 
 Control Strain  Marker Strain
Gene Affected
Origin This strain had maintained at Hokkaido University, School of Medicine from around 1980. F20 generation rats were transferred to Health Sciences University of Hokkaido in 1987.
Strain characteristics Control strain for SHRSP/Ezo (NBRP No.0441).
Breeding Conditions There is a possibility that express gait abnormality in rare cases.
Genotyping
References Ueno K-I, Togashi H, Mori K, Matsumoto M, Ohashi S, Hoshino A, Fujita T, Saito H, Minami M and Yoshioka M: Behavioural and pharmacological relevance of stroke-prone spontan eously hypertensive rats as an animal model of a developmental disorder. Behav Pharmacol 13: 1-13 (2002)

注意欠陥/多動性障害モデル, 幼若脳卒中易発症高血圧自然発症ラットの行動薬理学的特性 [ミニレビュー] 日本神経精神薬理学雑誌 (Jpn. J. Neuropsychopharmacol.) 23: 47-55 (2003)

Ueno K, Togashi H, Matsumoto M, Saito H, Yoshioka M.
Juvenile stroke-prone spontaneously hypertensive rats as an animal model of attention-deficit/hyperactivity disorder. Biogenic Amines 17 (4-6): 293-312 (2003)

Jesmin S, Togashi H, Sakuma I, Mowa CN, Ueno K, Yamaguchi T, Yoshioka M, Kitabatake A.
Gonadal hormones and frontocortical expression of vascular endothelial growth factor in male stroke-prone, spontaneously hypertensive rats, a model for attention-deficit/hyperactivity disorder.
Endocrinology. 2004 Sep;145(9):4330-43.

Togashi H, Ueno K, Yamaguchi T, Matsumoto M, Higuchi K, Saito H, Yoshioka M.
Anxiety-related behavior in juvenile stroke-prone spontaneously hypertensive rats - an animal model of attention-deficit/hyperactivity disorder.
Biogenic Amines 18(3-6): 247-261 (2004)
Additional strain information