Strain information  NBRP Rat No: 0001  Strain name: ACI/NKyo  Commmon Name: August Copenhagen Irish Rat Genome Database Principal Investigator:  Tadao Serikawa  Graduate School of Medicine, Kyoto University       Yoshidakonoe-cho, Sakyo-ku    606-8501 Kyoto     JAPAN Tel: 075-753-4360    Fax: 075-753-4409 Email: serikawa@anim.med.kyoto-u.ac.jp Preservation Status:   Embryo        Sperm       Living Animals Coat Color  agouti (A,B,hi) Inbred Generations  F143+73 (March 2012) Usage Restrictions   Genetic Status   Inbred  Segregating   Congenic   Consomic   Recombinant   Coisogenic   Spont. Mutant  Transgene  Ind. Mutant  Category Other  Comercial Availability Research Category   Diabetes Obesity  Neurobiology  Ophthalmology   Dentistry  Cardio Hypertension  Cancer  Metabolism  Otorhinology  Immunology  Infectious  Osteosis   Internal Organ  Dermatology   Reproduction   Development  Behavior  Hematology  Urology   Pharmacology  Research Area Others   Control Strain  Marker Strain Gene Affected Origin NIH (1988, F143) > Kyo (F43) Strain characteristics Kitazawa Y, Ueta H, Sawanobori Y, Katakai T, Yoneyama H, Ueha S, Matsushima K, Tokuda N, Matsuno K. Novel Targeting to XCR1+ Dendritic Cells Using Allogeneic T Cells for Polytopical Antibody Responses in the Lymph Nodes. Front Immunol. 2019 May 29:10:1195. Spontaneous tumours 46% testes, 16% adrenal, 5% pituitary, 6% skin and ear duct and fewer of other types in males; 21% pituitary, 13% uterus, 11% mammary gland, 6% adrenal and fewer of other types in females. Other conditions include 28% of males and 20% of females with absent, hypoplastic or cystic kidneys on one side sometimes associated with an absent or defective uterine horn or atrophic testes on the same side (Maekawa and Odashima 1975). These abnormalities have a polygenic mode of inheritance (Cramer and Gill 1975). Breeding Conditions Usually good breeding performance but reduce litter size in case of females with agenesis of the uterine horn. Genotyping References Sung SY, Lin YW, Wu CC, Lin CY, Hsu PS, Periasamy S, Nagarajan B, Hsieh DJ, Tsai YT, Tsai CS, Lin FY. Supercritical carbon dioxide-decellularized arteries exhibit physiologic-like vessel regeneration following xenotransplantation in rats. Biomater Sci. 2023 Mar 28;11(7):2566-2580. Lin YW, Tsai CS, Huang CY, Tsai YT, Shih CM, Lin SJ, Li CY, Lin CY, Sung SY, Lin FY. Far-Infrared Therapy Decreases Orthotopic Allograft Transplantation Vasculopathy. Biomedicines. 2022 May 7;10(5):1089. Lin FY, Shih CM, Huang CY, Tsai YT, Loh SH, Li CY, Lin CY, Lin YW, Tsai CS. Dipeptidyl Peptidase-4 Inhibitor Decreases Allograft Vasculopathy Via Regulating the Functions of Endothelial Progenitor Cells in Normoglycemic Rats. Cardiovasc Drugs Ther. 2021 Dec;35(6):1111-1127. Ueta H, Xu XD, Yu B, Kitazawa Y, Yu E, Hara Y, Morita-Nakagawa M, Zhou S, Sawanobori Y, Ueha S, Rokutan K, Tanaka T, Tokuda N, Matsushima K, Matsuno K. Suppression of liver transplant rejection by anti-donor MHC antibodies via depletion of donor immunogenic dendritic cells. Int Immunol. 2021 Apr 22;33(5):261-272. Ara S, Miyazaki A, Hoang Trung H, Yokoe M, Nakagawa Y, Kaneko T, Kuramoto T. Long terminal repeat insertion in Kit causes unilateral renal agenesis in rats. Translat Regulat Sci. 2(1): 30–35, 2020 Kitazawa Y, Ueta H, Sawanobori Y, Katakai T, Yoneyama H, Ueha S, Matsushima K, Tokuda N, Matsuno K. Novel Targeting to XCR1+ Dendritic Cells Using Allogeneic T Cells for Polytopical Antibody Responses in the Lymph Nodes. Front Immunol. 2019 May 29:10:1195. Ueta H, Kitazawa Y, Sawanobori Y, Ueno T, Ueha S, Matsushima K, Matsuno K. Single blood transfusion induces the production of donor-specific alloantibodies and regulatory T cells mainly in the spleen. Int Immunol. 2018 Jan 18. [Epub ahead of print] Kuramoto T, Nakanishi S, Ochiai M, Nakagama H, Voigt B, Serikawa T. Origins of Albino and Hooded Rats: Implications from Molecular Genetic Analysis across Modern Laboratory Rat Strains. PLoS One. 2012;7(8):e43059. Kuramoto T, Yokoe M, Hashimoto R, Hiai H, Serikawa T. A rat model of hypohidrotic ectodermal dysplasia carries a missense mutation in the Edaradd gene. BMC Genetics 12:91, 2011 Matsuno K, Ueta H, Shu Z, Xue-Dong X, Sawanobori Y, Kitazawa Y, Bin Y, Yamashita M, Shi C. The microstructure of secondary lymphoid organs that support immune cell trafficking. Arch Histol Cytol. 2010;73(1):1-21. Review. LinksShull JD, Lachel CM, Strecker TE, Spady TJ, Tochacek M, Pennington KL, Murrin CR, Meza JL, Schaffer BS, Flood LA, Gould KA. Genetic bases of renal agenesis in the ACI rat: mapping of Renag1 to chromosome 14. Mamm Genome. 17(7):751-9, 2006. Additional strain information ACI