Strain information
 NBRP Rat No: 0001  Strain name: ACI/NKyo  Commmon Name: August Copenhagen Irish Rat Genome Database
Principal Investigator:  Tadao Serikawa  Graduate School of Medicine, Kyoto University       Yoshidakonoe-cho, Sakyo-ku    606-8501 Kyoto     JAPAN
Tel: 075-753-4360    Fax: 075-753-4409 Email:
Preservation Status:   Embryo        Sperm       Living Animals ../images/Photos/ACI NKyo/121a (Large).jpg ../images/Photos/ACI%20NKyo/121z%20(Large).jpg
Coat Color  agouti (A,B,hi)
Inbred Generations  F143+73 (March 2012)
Usage Restrictions  
Genetic Status
 Inbred  Segregating  Congenic  Consomic  Recombinant
 Coisogenic  Spont. Mutant  Transgene  Ind. Mutant  Category Other 
Comercial Availability
Research Category
 Diabetes Obesity  Neurobiology  Ophthalmology  Dentistry  Cardio Hypertension
 Cancer  Metabolism  Otorhinology  Immunology  Infectious
 Osteosis  Internal Organ  Dermatology  Reproduction  Development
 Behavior  Hematology  Urology  Pharmacology  Research Area Others 
 Control Strain  Marker Strain
Gene Affected
Origin NIH (1988, F143) > Kyo (F43)
Strain characteristics Spontaneous tumours 46% testes, 16% adrenal, 5% pituitary, 6% skin and ear duct and fewer of other types in males; 21% pituitary, 13% uterus, 11% mammary gland, 6% adrenal and fewer of other types in females. Other conditions include 28% of males and 20% of females with absent, hypoplastic or cystic kidneys on one side sometimes associated with an absent or defective uterine horn or atrophic testes on the same side (Maekawa and Odashima 1975). These abnormalities have a polygenic mode of inheritance (Cramer and Gill 1975).
Breeding Conditions Usually good breeding performance but reduce litter size in case of females with agenesis of the uterine horn.
References Ueta H, Kitazawa Y, Sawanobori Y, Ueno T, Ueha S, Matsushima K, Matsuno K.
Single blood transfusion induces the production of donor-specific alloantibodies and regulatory T cells mainly in the spleen.
Int Immunol. 2018 Jan 18. [Epub ahead of print]

Kuramoto T, Nakanishi S, Ochiai M, Nakagama H, Voigt B, Serikawa T.

Origins of Albino and Hooded Rats: Implications from Molecular Genetic Analysis across Modern Laboratory Rat Strains.

PLoS One. 2012;7(8):e43059.

Kuramoto T, Yokoe M, Hashimoto R, Hiai H, Serikawa T.

A rat model of hypohidrotic ectodermal dysplasia carries a missense mutation in the Edaradd gene.

BMC Genetics 12:91, 2011

Matsuno K, Ueta H, Shu Z, Xue-Dong X, Sawanobori Y, Kitazawa Y, Bin Y, Yamashita M, Shi C.

The microstructure of secondary lymphoid organs that support immune cell trafficking.

Arch Histol Cytol. 2010;73(1):1-21. Review.

LinksShull JD, Lachel CM, Strecker TE, Spady TJ, Tochacek M, Pennington KL, Murrin CR, Meza JL, Schaffer BS, Flood LA, Gould KA.

Genetic bases of renal agenesis in the ACI rat: mapping of Renag1 to chromosome 14.

Mamm Genome. 17(7):751-9, 2006.
Additional strain information ACI