Strain information
 NBRP Rat No: 0354  Strain name: TM.KDP-Cblb/Nyo  Commmon Name: TM.KDP-Cblb, TM.KDP-Cblb congenic Rat Genome Database
Principal Investigator:  Susumu Seino  Kobe University Graduate School of Medicine       7-5-1 Kusunoki-cho, Chuou-Ku, Kobe    650-0017 Hyogo     Japan
Tel: 078-382-5364    Fax: 078-382-5379 Email:,
Preservation Status:   Embryo        Sperm       Living Animals
Coat Color  a,B,C,h,P,r
Inbred Generations  N7F8
Usage Restrictions  The recipient of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR.The recipients shall cite the references of the resource and acknowledge the developer as the source of the resource in the publications. Depending on the project of the recipients, a collaborative arrangement with the developer could be required. In this case, the recipients shall discuss with the developer.
Genetic Status
 Inbred  Segregating  Congenic  Consomic  Recombinant
 Coisogenic  Spont. Mutant  Transgene  Ind. Mutant  Category Other 
Comercial Availability
Research Category
 Diabetes Obesity  Neurobiology  Ophthalmology  Dentistry  Cardio Hypertension
 Cancer  Metabolism  Otorhinology  Immunology  Infectious
 Osteosis  Internal Organ  Dermatology  Reproduction  Development
 Behavior  Hematology  Urology  Pharmacology  Research Area Others 
 Control Strain  Marker Strain
Gene Affected Cblb: Casitas B-lineage lymphoma b
Strain characteristics insulitis
Breeding Conditions Homozygous Cblb rats are usually infertile in both sexes and are therefore maintained by crossing heterozygous individuals (segregating inbred strain).
References Yokoi N, Komeda K, Wang HY, Yano H, Kitada K, Saitoh Y, Seino Y, Yasuda K, Serikawa T, Seino S.
Cblb is a major susceptibility gene for rat type 1 diabetes mellitus.
Nat Genet. 31(4):391-4, 2002

Yokoi N, Namae M, Fuse M, Wang HY, Hirata T, Seino S, Komeda K.
Establishment and characterization of the Komeda diabetes-prone rat as a segregating inbred strain.
Exp Anim. 52(4):295-301, 2003
Additional strain information