| NBRP Rat No: 0372 |
Strain name: MPOD/Kyo |
Commmon Name: MPOD, Myeloperoxidase deficient rat |
Rat Genome Database |
| Principal Investigator: |
Tadao Serikawa Graduate School of Medicine, Kyoto University Yoshidakonoe-cho, Sakyo-ku 606-8501 Kyoto JAPAN |
| Tel: 075-753-4360 Fax: 075-753-4409 |
Email: serikawa@anim.med.kyoto-u.ac.jp |
| Preservation Status: |
Embryo Sperm Living Animals |
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| Coat Color |
albino (c) |
| Inbred Generations |
F8+5 (May 2009) |
| Usage Restrictions |
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| Genetic Status |
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| Comercial Availability |
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| Research Category |
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| Gene Affected |
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| Origin |
Myeloperoxidase deficient rat was detected in Std:Wistar rats which were purchased from Japan SLC, Inc. in 2001. The causative gene is inherited as an autosomal recessive trait. |
| Strain characteristics |
Compared with normal rats, 1) female sexual maturation is late (about 20 weeks of age), 2) growing of progeny is late and poor lactation leads to death at an age of 2 or 3 days of age because of poor lactation, 3) litter size is small (about 5), 4) infant weight gain is reduced. (Nov 4, 2009) |
| Breeding Conditions |
Maintained by sib mating among homozygoutes which shows possitive peroxidase activity. |
| Genotyping |
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| References |
1. Sequence of the murine myeloperoxidase(MPO) gene; Venturelli, D. et al, Nucleic Acids Research Vol.17(19),7987-7988,1989
2. 公開特許公報 特開2000-116280（2000年4月25日公開） 発明の名称：ミエロペルオキシダーゼ遺伝子機能が欠損しているマウス |
| Additional strain information |
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