Strain information
 NBRP Rat No: 0372  Strain name: MPOD/Kyo  Commmon Name: MPOD, Myeloperoxidase deficient rat Rat Genome Database
Principal Investigator:  Tadao Serikawa  Graduate School of Medicine, Kyoto University       Yoshidakonoe-cho, Sakyo-ku    606-8501 Kyoto     JAPAN
Tel: 075-753-4360    Fax: 075-753-4409 Email:
Preservation Status:   Embryo        Sperm       Living Animals ../images/Photos/MPOD/MPOD_1024.jpg ../images/Photos/
Coat Color  albino (c)
Inbred Generations  F8+5 (May 2009)
Usage Restrictions  
Genetic Status
 Inbred  Segregating  Congenic  Consomic  Recombinant
 Coisogenic  Spont. Mutant  Transgene  Ind. Mutant  Category Other 
Comercial Availability
Research Category
 Diabetes Obesity  Neurobiology  Ophthalmology  Dentistry  Cardio Hypertension
 Cancer  Metabolism  Otorhinology  Immunology  Infectious
 Osteosis  Internal Organ  Dermatology  Reproduction  Development
 Behavior  Hematology  Urology  Pharmacology  Research Area Others 
 Control Strain  Marker Strain
Gene Affected
Origin Myeloperoxidase deficient rat was detected in Std:Wistar rats which were purchased from Japan SLC, Inc. in 2001. The causative gene is inherited as an autosomal recessive trait.
Strain characteristics Compared with normal rats, 1) female sexual maturation is late (about 20 weeks of age), 2) growing of progeny is late and poor lactation leads to death at an age of 2 or 3 days of age because of poor lactation, 3) litter size is small (about 5), 4) infant weight gain is reduced. (Nov 4, 2009)
Breeding Conditions Maintained by sib mating among homozygoutes which shows possitive peroxidase activity.
References 1. Sequence of the murine myeloperoxidase(MPO) gene; Venturelli, D. et al, Nucleic Acids Research Vol.17(19),7987-7988,1989

2. 公開特許公報 特開2000-116280(2000年4月25日公開) 発明の名称:ミエロペルオキシダーゼ遺伝子機能が欠損しているマウス
Additional strain information