Strain information

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NBRP Rat No: 0372

Strain name: MPOD/Kyo

Commmon Name: MPOD, Myeloperoxidase deficient rat

Rat Genome Database

Principal Investigator:

Tadao SerikawaGraduate School of Medicine, Kyoto University

Preservation Status:

Embryo Sperm Living Animals

Coat Color

albino (c)

Inbred Generations

F8+5 (May 2009)

Usage Restrictions

Genetic Status

Inbred Segregating Congenic Consomic Recombinant Coisogenic Spont. Mutant Transgene Ind. Mutant Category Other

Comercial Availability

Research Category

Diabetes Obesity Neurobiology Ophthalmology Dentistry Cardio Hypertension Cancer Metabolism Otorhinology Immunology Infectious Osteosis Internal Organ Dermatology Reproduction Development Behavior Hematology Urology Pharmacology Research Area Others

Control Strain Marker Strain

Gene Affected

Origin

Myeloperoxidase deficient rat was detected in Std:Wistar rats which were purchased from Japan SLC, Inc. in 2001. The causative gene is inherited as an autosomal recessive trait.

Strain characteristics

Compared with normal rats, 1) female sexual maturation is late (about 20 weeks of age), 2) growing of progeny is late and poor lactation leads to death at an age of 2 or 3 days of age because of poor lactation, 3) litter size is small (about 5), 4) infant weight gain is reduced. (Nov 4, 2009)

Breeding Conditions

Maintained by sib mating among homozygoutes which shows possitive peroxidase activity.

Genotyping

References

1. Sequence of the murine myeloperoxidase(MPO) gene; Venturelli, D. et al, Nucleic Acids Research Vol.17(19),7987-7988,1989

2. 公開特許公報　特開2000-116280（2000年4月25日公開）　発明の名称：ミエロペルオキシダーゼ遺伝子機能が欠損しているマウス

Additional strain information (Japanese only)