| NBRP Rat No: 0440 |
Strain name: KCI/Kyo |
Commmon Name: KCI, Kyoto circling rat, MCI |
Rat Genome Database |
| Principal Investigator: |
Tadao Serikawa Graduate School of Medicine, Kyoto University Yoshidakonoe-cho, Sakyo-ku 606-8501 Kyoto JAPAN |
| Tel: 075-753-4360 Fax: 075-753-4409 |
Email: serikawa@anim.med.kyoto-u.ac.jp |
| Preservation Status: |
Embryo Sperm Living Animals |
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| Coat Color |
albino (c) |
| Inbred Generations |
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| Usage Restrictions |
The recipient of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR.
For a commercial use of this resource, a new contract must be concluded between the depositor and the recipient. |
| Genetic Status |
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| Comercial Availability |
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| Research Category |
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| Gene Affected |
Pcdh15: protocadherin 15 |
| Origin |
Rats showing abnormal behaviors characterized by constant circling movements were found in the F3 generation of Crl:CD(SD) rats purchased from Charles River Laboratory Japan in 2003. |
| Strain characteristics |
Homozygous KCI rats display circling and abnormal swimming behaviors along with the lack of an auditory-evoked brainstem response at the highest intensities of acoustic stimulation. The mutation on the kci allele is a nonsense mutation and is predicted to result in truncated PCDH15 protein at the 9th domain of extracellular cadherin domains. Histological study revealed severe reduction of the cochlear hair cells and the ganglion cells in the adult KCI rats. |
| Breeding Conditions |
Heterozygous female and homozygous male are mated. |
| Genotyping |
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| References |
Naoi K, Kuramoto T, Kuwamura Y, Gohma H, Kuwamura M, Serikawa T.
Characterization of the Kyoto Circling (KCI) rat carrying a spontaneous nonsense mutation in the protocadherin 15 (Pcdh15) gene.
Exp Anim 58(1):1-10, 2009. |
| Additional strain information |
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