Strain information
 NBRP Rat No: 0440  Strain name: KCI/Kyo  Commmon Name: KCI, Kyoto circling rat, MCI Rat Genome Database
Principal Investigator:  Tadao Serikawa  Graduate School of Medicine, Kyoto University       Yoshidakonoe-cho, Sakyo-ku    606-8501 Kyoto     JAPAN
Tel: 075-753-4360    Fax: 075-753-4409 Email: serikawa@anim.med.kyoto-u.ac.jp
Preservation Status:   Embryo        Sperm       Living Animals ../images/Photos/circling_homo/1571a1024_malehomo.jpg ../images/Photos/circling_homo/1571z1024_malehomo.jpg
Coat Color  albino (c)
Inbred Generations  
Usage Restrictions  The recipient of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR.
For a commercial use of this resource, a new contract must be concluded between the depositor and the recipient.
Genetic Status
 Inbred  Segregating  Congenic  Consomic  Recombinant
 Coisogenic  Spont. Mutant  Transgene  Ind. Mutant  Category Other 
Comercial Availability
Research Category
 Diabetes Obesity  Neurobiology  Ophthalmology  Dentistry  Cardio Hypertension
 Cancer  Metabolism  Otorhinology  Immunology  Infectious
 Osteosis  Internal Organ  Dermatology  Reproduction  Development
 Behavior  Hematology  Urology  Pharmacology  Research Area Others 
 Control Strain  Marker Strain
Gene Affected Pcdh15: protocadherin 15
Origin Rats showing abnormal behaviors characterized by constant circling movements were found in the F3 generation of Crl:CD(SD) rats purchased from Charles River Laboratory Japan in 2003.
Strain characteristics Homozygous KCI rats display circling and abnormal swimming behaviors along with the lack of an auditory-evoked brainstem response at the highest intensities of acoustic stimulation. The mutation on the kci allele is a nonsense mutation and is predicted to result in truncated PCDH15 protein at the 9th domain of extracellular cadherin domains. Histological study revealed severe reduction of the cochlear hair cells and the ganglion cells in the adult KCI rats.
Breeding Conditions Heterozygous female and homozygous male are mated.
Genotyping
References Naoi K, Kuramoto T, Kuwamura Y, Gohma H, Kuwamura M, Serikawa T.
Characterization of the Kyoto Circling (KCI) rat carrying a spontaneous nonsense mutation in the protocadherin 15 (Pcdh15) gene.
Exp Anim 58(1):1-10, 2009.
Additional strain information