Strain information
 NBRP Rat No: 0298  Strain name: LEW-Tg(Gt(ROSA)26Sor-lacZ)44Jmsk  Commmon Name: LEW-Tg(Rosa-LacZ)44Jmsk, Rosa-lacZ44 Rat Genome Database
Principal Investigator:  Eiji Kobayashi  Center for Molecular Medicine, Jichi Medical School       3311-1, Yakushiji, Shimono-shi, Tochigi    329-0498 Tochigi     Japan
Tel: 0285-58-7446    Fax: 0285-44-5365 Email: eijikoba@jichi.ac.jp
Preservation Status:   Embryo        Sperm       Living Animals ../images/Photos/LEW-Tg_ROSA-LacZ_44Jmsk/LEW-Tg_ROSA-LacZ_44Jmsk_1024.jpg ../images/Photos/
Coat Color  albino (c)
Inbred Generations  F?+46 (April 2012)
Usage Restrictions  In publishing, the references designated by the DEPOSITOR are requested to be cited.
Genetic Status
 Inbred  Segregating  Congenic  Consomic  Recombinant
 Coisogenic  Spont. Mutant  Transgene  Ind. Mutant  Category Other 
Comercial Availability
Research Category
 Diabetes Obesity  Neurobiology  Ophthalmology  Dentistry  Cardio Hypertension
 Cancer  Metabolism  Otorhinology  Immunology  Infectious
 Osteosis  Internal Organ  Dermatology  Reproduction  Development
 Behavior  Hematology  Urology  Pharmacology  Research Area Others 
 Control Strain  Marker Strain
Gene Affected lacZ: beta-galactosidase, E. coli
Origin This strain was established at Jichi Medical School. This transgenic rat was originated from LEW (RT1l) strain purchased from Charles River Japan.
Strain characteristics This strain expresses LacZ ubiquitously driven by the gene trap ROSA26 promoter.
Breeding Conditions Good breeding performance.
Genotyping Genotyping protocol for modified LacZ
References Kodama A, Kamei N, Kamei G, Kongcharoensombat W, Ohkawa S, Nakabayashi A, Ochi M.
In vivo bioluminescence imaging of transplanted bone marrow mesenchymal stromal cells using a magnetic delivery system in a rat fracture model.
J Bone Joint Surg Br. 2012 Jul;94(7):998-1006.

Hata T, Uemoto S, Fujimoto Y, Murakami T, Tateno C, Yoshizato K, Kobayashi E.
Transplantation of Engineered Chimeric Liver With Autologous Hepatocytes and Xenobiotic Scaffold.
Ann Surg. 2013 Mar;257(3):542-7.

Tanaka H, Arimura Y, Yabana T, Goto A, Hosokawa M, Nagaishi K, Yamashita K, Yamamoto H, Sasaki Y, Fujimiya M, Imai K, Shinomura Y.
Myogenic lineage differentiated mesenchymal stem cells enhance recovery from dextran sulfate sodium-induced colitis in the rat.
J Gastroenterol. 2011 Feb;46(2):143-52.

Inoue H, Ohsawa I, Murakami T, Kimura A, Hakamata Y, Sato Y, Kaneko T, Takahashi M, Okada T, Ozawa K, Francis J, Leone P, Kobayashi E.
Development of new inbred transgenic strains of rats with LacZ or GFP.
Biochem Biophys Res Commun. 2005 Apr 1;329(1):288-95.
Additional strain information LEW