Strain information
 NBRP Rat No: 0299  Strain name: LEW-Tg(Gt(ROSA)26Sor-luc)11Jmsk  Commmon Name: LEW-Tg(Rosa-luc)11Jmsk, Luc11 Rat Genome Database
Principal Investigator:  Eiji Kobayashi  Center for Molecular Medicine, Jichi Medical School       3311-1, Yakushiji, Shimono-shi, Tochigi    329-0498 Tochigi     Japan
Tel: 0285-58-7446    Fax: 0285-44-5365 Email: eijikoba@jichi.ac.jp
Preservation Status:   Embryo        Sperm       Living Animals ../images/Photos/0299/P1040679.JPG
Coat Color  
Inbred Generations  F11(March 2012)
Usage Restrictions  In publishing, the references designated by the DEPOSITOR are requested to be cited.
Genetic Status
 Inbred  Segregating  Congenic  Consomic  Recombinant
 Coisogenic  Spont. Mutant  Transgene  Ind. Mutant  Category Other 
Comercial Availability
Research Category
 Diabetes Obesity  Neurobiology  Ophthalmology  Dentistry  Cardio Hypertension
 Cancer  Metabolism  Otorhinology  Immunology  Infectious
 Osteosis  Internal Organ  Dermatology  Reproduction  Development
 Behavior  Hematology  Urology  Pharmacology  Research Area Others 
 Control Strain  Marker Strain
Gene Affected luc: luciferase, firefly
Origin This strain was established at Jichi Medical School. This transgenic rat was originated from LEW (RT1l) strain purchased from Charles River Japan.
Strain characteristics This strain expresses luciferase driven by the gene trap ROSA 26 promoter.
Breeding Conditions Good breeding performance.
Genotyping Genotyping protocol for Luc
References Hladíková Z, Voglova B, Pátíková A, Berkova Z, Kříž J, Vojtíškov A, Leontovyc I, Jirák D, Saudek F.
Bioluminescence Imaging In Vivo Confirms the Viability of Pancreatic Islets Transplanted into the Greater Omentum.
Mol Imaging Biol. 2021 Oct;23(5):639-649.

Galisova A, Herynek V, Swider E, Sticova E, Pátikova A, Kosinova L, Kriz J, Hajek M, Srinivas M, Jirak D.
A Trimodal Imaging Platform for Tracking Viable Transplanted Pancreatic Islets In Vivo: F-19 MR, Fluorescence, and Bioluminescence Imaging.
Mol Imaging Biol. 2019 Jun;21(3):454-464.

Herynek V, Turnovcova K, Galisova A, Kaman O, Marekova D, Koktan J, Vosmanska M, Kosinova L, Jendelova P.
Manganese-Zinc Ferrites: Safe and Efficient Nanolabels for Cell Imaging and Tracking In Vivo.
ChemistryOpen. 2019 Jan 23;8(2):155-165.

Gálisová A, Fábryová E, Sticová E, Kosinová L, Jirátová M, Herynek V, Berková Z, Kříž J, Hájek M, Jirák D.
The Optimal Timing for Pancreatic Islet Transplantation into Subcutaneous Scaffolds Assessed by Multimodal Imaging.
Contrast Media Mol Imaging. 2017 Dec 26;2017:5418495

Gálisová A, Fábryová E, Jirák D, Sticová E, Lodererová A, Herynek V, Kříž J, Hájek M.
Multimodal Imaging Reveals Improvement of Blood Supply to an Artificial Cell Transplant Site Induced by Bioluminescent Mesenchymal Stem Cells.
Mol Imaging Biol. 2017 Feb;19(1):15-23.

Nakabayashi A, Kamei N, Sunagawa T, Suzuki O, Ohkawa S, Kodama A, Kamei G, Ochi M.
In vivo bioluminescence imaging of magnetically targeted bone marrow-derived mesenchymal stem cells in skeletal muscle injury model.
J Orthop Res. 2013 May;31(5):754-9.

Kodama A, Kamei N, Kamei G, Kongcharoensombat W, Ohkawa S, Nakabayashi A, Ochi M.
In vivo bioluminescence imaging of transplanted bone marrow mesenchymal stromal cells using a magnetic delivery system in a rat fracture model.
J Bone Joint Surg Br. 2012 Jul;94(7):998-1006.

Hata T, Iwasaki J, Hishikawa S, Fujimoto Y, Uemoto S, Kobayashi E.
Development of a portocaval shunt using a small intestinal segment in rats.
Microsurgery. 2010 May;30(4):302-6.

Iwasaki J, Hata T, Hishikawa S, Fujimoto Y, Uemoto S, Murakami T, Kobayashi E.
Use of rat segmental intestine for fetal pancreatic transplantation.
Microsurgery. 2010 May;30(4):296-301.

Hakamata Y, Murakami T, Kobayashi E.
"Firefly rats" as an organ/cellular source for long-term in vivo bioluminescent imaging.
Transplantation. 2006 Apr 27;81(8):1179-84.
Additional strain information LEW