Strain information  NBRP Rat No: 0301  Strain name: DA-Tg(Alb-HSVtk)5Jmsk  Commmon Name: tk5 Rat Genome Database Principal Investigator:  Eiji Kobayashi  Center for Molecular Medicine, Jichi Medical School       3311-1, Yakushiji, Shimono-shi, Tochigi    329-0498 Tochigi     Japan Tel: 0285-58-7446    Fax: 0285-44-5365 Email: eijikoba@jichi.ac.jp Preservation Status:   Embryo        Sperm       Living Animals Coat Color   Inbred Generations   Usage Restrictions  In publishing, the references designated by the DEPOSITOR are requested to be cited. Genetic Status   Inbred  Segregating   Congenic   Consomic   Recombinant   Coisogenic   Spont. Mutant  Transgene  Ind. Mutant  Category Other  Comercial Availability Research Category   Diabetes Obesity  Neurobiology  Ophthalmology   Dentistry  Cardio Hypertension  Cancer  Metabolism  Otorhinology  Immunology  Infectious  Osteosis   Internal Organ  Dermatology   Reproduction   Development  Behavior  Hematology  Urology   Pharmacology  Research Area Others   Control Strain  Marker Strain Gene Affected HSVtk: herpes simplex virus thymidine kinase, Alb:Albumin Origin This strain was established at Jichi Medical School. Strain characteristics This strain expresses HSVtk (herpes simplex virus thymidine kinase) liver-specific driven by mouse albumin enhancer/promoter. Administration of injection ganciclovir (GCV) in this transgenic rats causes hepatitis. Breeding Conditions Male infertility. Genotyping References Kawasaki M, Fujino M, Li XK, Kitazawa Y, Funeshima N, Takahashi R, Ueda M, Amano T, Hakamata Y, Kobayashi E. Inducible liver injury in the transgenic rat by expressing liver-specific suicide gene. Biochem Biophys Res Commun. 28;311(4):920-8, 2003. Additional strain information