| NBRP Rat No: 0376 |
Strain name: SD-Tg(HRAS)128Htsu |
Commmon Name: SD-Tg(hHRAS)128, Hras128 |
Rat Genome Database |
| Principal Investigator: |
Hiroyuki Tsuda Nagoya City University Graduate School of Medical Sciences 1 Kawasumi, Mizuho-cho Mizuho-ku, Nagoya 467-8601 Aichi Japan |
| Tel: 052-853-8992 Fax: 052-853-8996 |
Email: htsuda@med.nagoya-cu.ac.jp |
| Preservation Status: |
Embryo Sperm Living Animals |
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| Coat Color |
albino (c) |
| Inbred Generations |
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| Usage Restrictions |
The recipient of BIOLOGICAL RESOURCE shall obtain prior written consent concerning usage from the DEPOSITOR. |
| Genetic Status |
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| Comercial Availability |
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| Research Category |
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| Gene Affected |
HRAS: v-Ha-ras Harvey rat sarcoma viral oncogene homolog [ Homo sapiens ] |
| Origin |
This transgenic strain was generated by pronuclear injection of the transgene. |
| Strain characteristics |
This strain is carrying three copies of the human c-Ha-ras proto-oncogene, including its own promoter region. The rats are extremely sensitive to the induction of mammary carcinomas induced by chemical carcinogen such as DMBA and MNU. |
| Breeding Conditions |
Maintained as hemizygous males. |
| Genotyping |
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| References |
Nohmi T, Masumura K, Toyoda-Hokaiwado N.
Transgenic rat models for mutagenesis and carcinogenesis.
Genes Environ. 2017 Feb 1;39:11.
Tsuda H, Fukamachi K, Ohshima Y, Ueda S, Matsuoka Y, Hamaguchi T, Ohnishi T, Takasuka N, Naito A.
High susceptibility of human c-Ha-ras proto-oncogene transgenic rats to carcinogenesis: a cancer-prone animal model.
Cancer Sci. 2005 96(6):309-16.
Asamoto M, Ochiya T, Toriyama-Baba H, Ota T, Sekiya T, Terada M, Tsuda H.
Transgenic rats carrying human c-Ha-ras proto-oncogenes are highly susceptible to N-methyl-N-nitrosourea mammary carcinogenesis.
Carcinogenesis. 2000 21(2):243-9. |
| Additional strain information |
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