Strain information
 NBRP Rat No: 0376  Strain name: SD-Tg(HRAS)128Htsu  Commmon Name: SD-Tg(hHRAS)128, Hras128 Rat Genome Database
Principal Investigator:  Hiroyuki Tsuda   Nagoya City University Graduate School of Medical Sciences       1 Kawasumi, Mizuho-cho Mizuho-ku, Nagoya    467-8601 Aichi     Japan
Tel: 052-853-8992    Fax: 052-853-8996 Email: htsuda@med.nagoya-cu.ac.jp
Preservation Status:   Embryo        Sperm       Living Animals
Coat Color  albino (c)
Inbred Generations  
Usage Restrictions  The recipient of BIOLOGICAL RESOURCE shall obtain prior written consent concerning usage from the DEPOSITOR.
Genetic Status
 Inbred  Segregating  Congenic  Consomic  Recombinant
 Coisogenic  Spont. Mutant  Genetically Modified (GM)  Ind. Mutant  Category Other 
Comercial Availability
Research Category
 Diabetes Obesity  Neurobiology  Ophthalmology  Dentistry  Cardio Hypertension
 Cancer  Metabolism  Otorhinology  Immunology  Infectious
 Osteosis  Internal Organ  Dermatology  Reproduction  Development
 Behavior  Hematology  Urology  Pharmacology  Research Area Others 
 Control Strain  Marker Strain
Gene Affected HRAS: v-Ha-ras Harvey rat sarcoma viral oncogene homolog [ Homo sapiens ]
Origin This transgenic strain was generated by pronuclear injection of the transgene.
Strain characteristics This strain is carrying three copies of the human c-Ha-ras proto-oncogene, including its own promoter region. The rats are extremely sensitive to the induction of mammary carcinomas induced by chemical carcinogen such as DMBA and MNU.
Breeding Conditions Maintained as hemizygous males.
Genotyping
References Nohmi T, Masumura K, Toyoda-Hokaiwado N.
Transgenic rat models for mutagenesis and carcinogenesis.
Genes Environ. 2017 Feb 1;39:11.

Tsuda H, Fukamachi K, Ohshima Y, Ueda S, Matsuoka Y, Hamaguchi T, Ohnishi T, Takasuka N, Naito A.
High susceptibility of human c-Ha-ras proto-oncogene transgenic rats to carcinogenesis: a cancer-prone animal model.
Cancer Sci. 2005 96(6):309-16.

Asamoto M, Ochiya T, Toriyama-Baba H, Ota T, Sekiya T, Terada M, Tsuda H.
Transgenic rats carrying human c-Ha-ras proto-oncogenes are highly susceptible to N-methyl-N-nitrosourea mammary carcinogenesis.
Carcinogenesis. 2000 21(2):243-9.
Additional strain information