Strain information  NBRP Rat No: 0041  Strain name: LEA/Hok  Commmon Name: KEA, Long Evans Agouti Rat Genome Database Principal Investigator:  Kazuhiro Kitada  Creative Research Initiative "Sousei", Hokkaido University       Kita 10 Nishi 8, Kita-ku    060-0810 Hokkaido     JAPAN Tel: 011-706-3582    Fax: 011-726-3476 Email: kkitada@cast.hokudai.ac.jp Preservation Status:   Embryo        Sperm       Living Animals Coat Color  agouti (A,B,C,h) Inbred Generations  F102 (Jul 2007) Usage Restrictions   Genetic Status   Inbred  Segregating   Congenic   Consomic   Recombinant   Coisogenic   Spont. Mutant  Transgene  Ind. Mutant  Category Other  Comercial Availability Research Category   Diabetes Obesity  Neurobiology  Ophthalmology   Dentistry  Cardio Hypertension  Cancer  Metabolism  Otorhinology  Immunology  Infectious  Osteosis   Internal Organ  Dermatology   Reproduction   Development  Behavior  Hematology  Urology   Pharmacology  Research Area Others   Control Strain  Marker Strain Gene Affected Origin Kobe university→Hokkaido University, Laboratory of Experimental Animal Science(Hok) 1975→Hokkaido University, Center for Experimental Plants & Animals(Hok) 1982, F19. Long Evans Agouti derived originally from an outbred Long Evans stock at Hokkaido University and selected for agouti coat colour (though Long Evans stock is usually fixed for non-agouti, hooded genes). Strain characteristics The LEA rat was established from a Long-Evans rat closed colony as the control strain of the LEC rat, which is reported to exhibit several mutant phenotypes such as hepatic disorder (hts), blockage of the T cell differentiation (thid) and X-ray hypersensitivity (xhs1 and xhs2). But LEA rat is hypersensitive to X-rays to a similar degree as the LEC rat. Breeding Conditions Good breeding performance. Sib-mating. Genotyping References Shimizu Y, Yanobu-Takanashi R, Nakano K, Hamase K, Shimizu T, Okamura T. A deletion in the Ctns gene causes renal tubular dysfunction and cystine accumulation in LEA/Tohm rats. Mamm Genome. 2019 Feb;30(1-2):23-33. Igarashi M, Hippo Y, Ochiai M, Fukuda H, Nakagama H. AKT is critically involved in cooperation between obesity and the dietary carcinogen amino-1-methyl-6-phenylimidazo [4,5-b] (PhIP) toward colon carcinogenesis in rats. Biochem Biophys Res Commun. 2013 Dec 13. pii: S0006-291X(13)02128-1. Torigoe D, Ichii O, Dang R, Ohnaka T, Okano S, Sasaki N, Kon Y, Agui T. High-resolution linkage mapping of the rat hooded locus. J Vet Med Sci. 2011 May;73(5):707-10. Agui T, Miyamoto T, Tsumagari T X-ray hypersensitivity in the LEA rat: genetic linkage analysis of responsible loci. Exp Anim. 50(2):147-51, 2001. Additional strain information LEA