Strain information
NBRP Rat No: 0401
Strain name
: ACI.F344-(
D16Rat12-D16Mco2
)/Nkg
Commmon Name: ACI.F344-(
D16Rat12-D16Mco2
)
Rat Genome Database
Principal Investigator:
Hitoshi Nakagama National Cancer center 5-1-1 Tsukiji, Chuo-ku 104-0045 Tokyo Japan
Tel: 03-3542-2511 Fax: 03-3542-2530
Email: hnakagam@ncc.go.jp
Preservation Status:
Embryo
Sperm
Living Animals
Coat Color
agouti
Inbred Generations
F9 (07.3.13)
Usage Restrictions
In publishing, an acknowledgment to the DEPOSITOR is requested.
Genetic Status
Inbred
Segregating
Congenic
Consomic
Recombinant
Coisogenic
Spont. Mutant
Transgene
Ind. Mutant
Category Other
Comercial Availability
Research Category
Diabetes Obesity
Neurobiology
Ophthalmology
Dentistry
Cardio Hypertension
Cancer
Metabolism
Otorhinology
Immunology
Infectious
Osteosis
Internal Organ
Dermatology
Reproduction
Development
Behavior
Hematology
Urology
Pharmacology
Research Area Others
Control Strain
Marker Strain
Gene Affected
Origin
F344 rats are susceptible and ACI rats are resistant to PhIP (2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine)-induced ACF (aberrant crypt foci) formation (Nagao, 1998). This congenic strain was established using 'speed congenic' method by backcrossing (F344/JclxACI/N)F1 onto ACI/N, followed by intercrossing in N8 generation. Thereafter this strain is maintained by crossing homozygous individuals. (Jul 7, 2009)
Strain characteristics
ACF formation induced by feeding 2-weeks PhIP-containing diet and 4-weeks high-fat diet is higher in this congenic strain than that in ACI/N strain. (Jul 7, 2009)
Breeding Conditions
Genotyping
References
Additional strain information