Strain information

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NBRP Rat No: 0402

Strain name: DA-Tg(Alb-TTR*V30M)7Jmsk

Commmon Name: DA-Tg(Alb-ATTR)7Jmsk, ATTR7

Rat Genome Database

Principal Investigator:

Eiji KobayashiCenter for Molecular Medicine, Jichi Medical School

Preservation Status:

Embryo Sperm Living Animals

Coat Color

Inbred Generations

Usage Restrictions

In publishing, the references designated by the DEPOSITOR is requested to be cited, and an acknowledgment to the DEPOSITOR is requested.

Genetic Status

Inbred Segregating Congenic Consomic Recombinant Coisogenic Spont. Mutant Transgene Ind. Mutant Category Other

Comercial Availability

Research Category

Diabetes Obesity Neurobiology Ophthalmology Dentistry Cardio Hypertension Cancer Metabolism Otorhinology Immunology Infectious Osteosis Internal Organ Dermatology Reproduction Development Behavior Hematology Urology Pharmacology Research Area Others

Control Strain Marker Strain

Gene Affected

transthyretin: TTR (human Amyloidogenic transthyretin (ATTR) V30M)

Origin

This strain was established at Jichi Medical School.

Strain characteristics

This is the strain expresses human Amyloidogenic transthyretin (ATTR) V30M driven by the mouse albumin enhancer/promoter, may be a useful animal model for the liver transplantation studies.

Breeding Conditions

Genotyping

References

Ueda M, Ando Y, Hakamata Y, Nakamura M, Yamashita T, Obayashi K, Himeno S, Inoue S, Sato Y, Kaneko T, Takamune N, Misumi S, Shoji S, Uchino M, Kobayashi E.
A transgenic rat with the human ATTR V30M: a novel tool for analyses of ATTR metabolisms.
Biochem Biophys Res Commun. 12;352(2):299-304, 2007.

Additional strain information (Japanese only)