Strain information
 NBRP Rat No: 0443  Strain name: F344-Apcm1Kyo  Commmon Name: F344-ApcKyo1588/Kyo, Apc delta 2523, Kyoto Apc Delta rat Rat Genome Database
Principal Investigator:  Takashi Kuramoto  Graduate School of Medicine, Kyoto University       Yoshidakonoe-cho, Sakyo-ku    606-8501 Kyoto     Japan
Tel: 075-753-4494    Fax: 075-753-4409 Email: kuramot@anim.med.kyoto-u.ac.jp
Preservation Status:   Embryo        Sperm       Living Animals ../images/Photos/Apc_Kyo1588_hetero/2041a1024.jpg ../images/Photos/Apc_Kyo1588_hetero/2041z1024.jpg
Coat Color  albino (c)
Inbred Generations  N12 F5 (April 2012)
Usage Restrictions  The recipient of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR.
For a commercial use of this resource, a new contract must be concluded between the depositor and the recipient.
Genetic Status
 Inbred  Segregating  Congenic  Consomic  Recombinant
 Coisogenic  Spont. Mutant  Transgene  Ind. Mutant  Category Other 
Comercial Availability Japan SLC, Inc
Research Category
 Diabetes Obesity  Neurobiology  Ophthalmology  Dentistry  Cardio Hypertension
 Cancer  Metabolism  Otorhinology  Immunology  Infectious
 Osteosis  Internal Organ  Dermatology  Reproduction  Development
 Behavior  Hematology  Urology  Pharmacology  Research Area Others 
 Control Strain  Marker Strain
Gene Affected Apc: adenomatous polyposis coli
Origin Established by ENU mutagenesis (gene-driven).　Background strain: F344/NSlc
Strain characteristics A point mutation　(S2523X) in Apc gene. This strain is an efficient rat model for colitis-associated colorectal cancer, azoxymethane and dextran sodium sulfate (AOM/DSS)-induced colon carcinogenesis
Breeding Conditions
Genotyping Genotyping protocol for Apc
References Kochi T, Shimizu M, Shirakami Y, Yoshimi K, Kuramoto T, Tanaka T, Moriwaki H.
Utility of Apc-mutant rats with a colitis-associated colon carcinogenesis model for chemoprevention studies.
Eur J Cancer Prev. 2015 May;24(3):180-7.

Irving AA, Yoshimi K, Hart ML, Parker T, Clipson L, Ford MR, Kuramoto T, Dove WF, Amos-Landgraf JM.
The utility of Apc-mutant rats in modeling human colon cancer.
Dis Model Mech. 7(11):1215-1225, 2014.

Tanaka T, Shimizu M, Kochi T, Shirakami Y, Mori T, Watanabe N, Naiki T, Moriwaki H, Yoshimi K, Serikawa T, Kuramoto T.
Apc-Mutant Kyoto Apc Delta (KAD) Rats Are Susceptible to 4-NQO-Induced Tongue Carcinogenesis.
Cancers. 2014 Jul 21;6(3):1522-39.

Yoshimi K, Tanaka T, Serikawa T, Kuramoto T.
Tumor Suppressor APC Protein Is Essential in Mucosal Repair from Colonic Inflammation through Angiogenesis.
Am J Pathol. 2013 Apr;182(4):1263-74.

Yoshimi K, Hashimoto T, Niwa Y, Hata K, Serikawa T, Tanaka T, Kuramoto T.
Use of a chemically induced-colon carcinogenesis-prone Apc-mutant rat in a chemotherapeutic bioassay.
BMC Cancer. 2012 Oct 3;12(1):448.

Yoshimi K, Tanaka T, Takizawa A, Kato M, Hirabayashi M, Mashimo T, Serikawa T, Kuramoto T.
Enhanced colitis-associated colon carcinogenesis in a novel Apc mutant rat.
Cancer Sci. 2009 Nov;100(11):2022-7.

吉見一人、真下知士、滝澤明子、加藤めぐみ、平林真澄、芹川忠夫、庫本高志
Kyoto Apc Deltaラットを用いた大腸腫瘍誘発試験
関西実験動物研究会第100回記念大会 2008.12.5
Additional strain information