Strain information  NBRP Rat No: 0456  Strain name: F344-Scn1am2Kyo  Commmon Name: F344/NSlc-Scn1aKyo631 Rat Genome Database Principal Investigator:  Tadao Serikawa  Graduate School of Medicine, Kyoto University       Yoshidakonoe-cho, Sakyo-ku    606-8501 Kyoto     JAPAN Tel: 075-753-4360    Fax: 075-753-4409 Email: serikawa@anim.med.kyoto-u.ac.jp Preservation Status:   Embryo        Sperm       Living Animals Coat Color  albino (c) Inbred Generations  N8 (May 2009) Usage Restrictions   The recipient of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR. For a commercial use of this resource, a new contract must be concluded between the depositor and the recipient. Genetic Status   Inbred  Segregating   Congenic   Consomic   Recombinant   Coisogenic   Spont. Mutant  Transgene  Ind. Mutant  Category Other  Comercial Availability Research Category   Diabetes Obesity  Neurobiology  Ophthalmology   Dentistry  Cardio Hypertension  Cancer  Metabolism  Otorhinology  Immunology  Infectious  Osteosis   Internal Organ  Dermatology   Reproduction   Development  Behavior  Hematology  Urology   Pharmacology  Research Area Others   Control Strain  Marker Strain Gene Affected Scn1a: sodium channel, voltage-gated, type I, alpha Origin This strain was established by ENU mutagenesis (gene-driven). This strain possesses a point mutation in the Scn1a gene (E539A) (Mashimo, 2010). (Jun 4, 2010) Strain characteristics A point mutation in Scn1a gene. Please refer to F344-Scn1am2Kyo (NBRP No.0455). (Jun 4, 2010) Breeding Conditions Good breeding performance. Genotyping Genotyping protocol forScn1am2Kyo References A missense mutation of the gene encoding voltage-dependent sodium channel (Nav1.1) confers susceptibility to febrile seizures in rats. Mashimo T, Ohmori I, Ouchida M, Ohno Y, Tsurumi T, Miki T, Wakamori M, Ishihara S, Yoshida T, Takizawa A, Kato M, Hirabayashi M, Sasa M, Mori Y, Serikawa T. J Neurosci. 2010 Apr 21;30(16):5744-53. Additional strain information