Strain information
 NBRP Rat No: 0456  Strain name: F344-Scn1am2Kyo  Commmon Name: F344/NSlc-Scn1aKyo631 Rat Genome Database
Principal Investigator:  Tadao Serikawa  Graduate School of Medicine, Kyoto University       Yoshidakonoe-cho, Sakyo-ku    606-8501 Kyoto     JAPAN
Tel: 075-753-4360    Fax: 075-753-4409 Email:
Preservation Status:   Embryo        Sperm       Living Animals ../images/Photos/F344_ScnlaKyo631_homo/1951a1024.jpg ../images/Photos/F344_ScnlaKyo631_homo/1951z1024.jpg
Coat Color  albino (c)
Inbred Generations  N8 (May 2009)
Usage Restrictions   The recipient of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR.
For a commercial use of this resource, a new contract must be concluded between the depositor and the recipient.
Genetic Status
 Inbred  Segregating  Congenic  Consomic  Recombinant
 Coisogenic  Spont. Mutant  Transgene  Ind. Mutant  Category Other 
Comercial Availability
Research Category
 Diabetes Obesity  Neurobiology  Ophthalmology  Dentistry  Cardio Hypertension
 Cancer  Metabolism  Otorhinology  Immunology  Infectious
 Osteosis  Internal Organ  Dermatology  Reproduction  Development
 Behavior  Hematology  Urology  Pharmacology  Research Area Others 
 Control Strain  Marker Strain
Gene Affected Scn1a: sodium channel, voltage-gated, type I, alpha
Origin This strain was established by ENU mutagenesis (gene-driven). This strain possesses a point mutation in the Scn1a gene (E539A) (Mashimo, 2010). (Jun 4, 2010)
Strain characteristics A point mutation in Scn1a gene. Please refer to F344-Scn1am2Kyo (NBRP No.0455). (Jun 4, 2010)
Breeding Conditions Good breeding performance.
Genotyping Genotyping protocol forScn1am2Kyo
References A missense mutation of the gene encoding voltage-dependent sodium channel (Nav1.1) confers susceptibility to febrile seizures in rats.
Mashimo T, Ohmori I, Ouchida M, Ohno Y, Tsurumi T, Miki T, Wakamori M, Ishihara S, Yoshida T, Takizawa A, Kato M, Hirabayashi M, Sasa M, Mori Y, Serikawa T.
J Neurosci. 2010 Apr 21;30(16):5744-53.
Additional strain information