Strain information  NBRP Rat No: 0464  Strain name: F344-Oune/Kyo  Commmon Name: Oune, Kyo734 Rat Genome Database Principal Investigator:  Tomoji Mashimo  The University of Tokyo, The Institute of Medical Science       4-6-1 Shirokanedai-Minatoku-Tokyoto    108-8639      Japan Tel: 03-6409-2489    Fax:  Email: mashimo@ims.u-tokyo.ac.jp Preservation Status:   Embryo        Sperm       Living Animals Coat Color  albino (c) Inbred Generations  N17 (April 2012) Usage Restrictions  The recipient of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR. For a commercial use of this resource, a new contract must be concluded between the depositor and the recipient. Genetic Status   Inbred  Segregating   Congenic   Consomic   Recombinant   Coisogenic   Spont. Mutant  Transgene  Ind. Mutant  Category Other  Comercial Availability Research Category   Diabetes Obesity  Neurobiology  Ophthalmology   Dentistry  Cardio Hypertension  Cancer  Metabolism  Otorhinology  Immunology  Infectious  Osteosis   Internal Organ  Dermatology   Reproduction   Development  Behavior  Hematology  Urology   Pharmacology  Research Area Others   Control Strain  Marker Strain Gene Affected Origin A mutant rat showing abnormal tail was found in the G1 rats produced by ENU mutagenesis (phenotype-driven). A misssense mutation in the Tbx6 gene was identified (Abe et. al, 2015) Strain characteristics Morphological defect of tail. Body length is short. Breeding Conditions Male rats show good breeding performance. Some females show poor breeding performance. Maintained in heterozygous condition by backcrossing onto F344/NSlc. Genotyping Determined by phenotype. References Novel ENU-Induced Mutation in Tbx6 Causes Dominant Spondylocostal Dysostosis-Like Vertebral Malformations in the Rat. Abe K, Takamatsu N, Ishikawa K, Tsurumi T, Tanimoto S, Sakurai Y, Lisse T, Imai K, Serikawa T, Mashimo T. PLoS One. 2015 Jun 19;10(6):e0130231. doi: 10.1371/journal.pone.0130231. eCollection 2015. Additional strain information