NBRP Rat No: 0458 |
Strain name: F344-Adms/Kyo |
Commmon Name: ADMS(autosomal dominant myokymia and seizures)rat, KER(Kyoto Epileptic Rat), Boo |
Rat Genome Database |
Principal Investigator: |
Tomoji Mashimo The University of Tokyo, The Institute of Medical Science 4-6-1 Shirokanedai-Minatoku-Tokyoto 108-8639 Japan |
Tel: 03-6409-2489 Fax: |
Email: mashimo@ims.u-tokyo.ac.jp |
Preservation Status: |
Embryo Sperm Living Animals |
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Coat Color |
albino (c) |
Inbred Generations |
N7 (May 2009) |
Usage Restrictions |
The recipient of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR. For a commercial use of this resource, a new contract must be concluded between the depositor and the recipient. |
Genetic Status |
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Comercial Availability |
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Research Category |
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Gene Affected |
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Origin |
This strain was established by phenotype-driven ENU mutagenesis. |
Strain characteristics |
ADMS rats dominantly exhibited myokymia, neuromyotonia and generalized tonic-clonic seizures. They also showed cold stress-induced tremor, neuromyotonia, and motor incoordination. Key words: myokymia, neuromyotonia, epilepsy |
Breeding Conditions |
Good breeding performance until seizure onset (about 4 or 5 months of age). Heterozygous females have less performance of nursing behavior for their pups. |
Genotyping |
Genotyping protocol for Kcna1 |
References |
Serikawa T, Mashimo T, Kuramoto T, Voigt B, Ohno Y, Sasa M.
Advances on Genetic Rat Models of Epilepsy.
Exp Anim. 64(1):1-7, 2015.
Ishida S, Sakamoto Y, Nishio T, Baulac S, Kuwamura M, Ohno Y, Takizawa A, Kaneko S, Serikawa T, Mashimo T.
Kcna1-mutant rats dominantly display myokymia, neuromyotonia and spontaneous epileptic seizures.
Brain Res. 2012 Jan 30;1435:154-66. |
Additional strain information |
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